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EC number: 211-750-5 | CAS number: 693-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Most of it performed under GLP, well documented. Analytical method not sensitive enough.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Practical Guidelines for Mutagenicity and Hydrolysis Data requested by SCF". Appendix 2: "Hydrolysis data" Issued by The Commission of the European Communities.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- in vitro
Test material
- Reference substance name:
- Dioctadecyl 3,3'-thiodipropionate
- EC Number:
- 211-750-5
- EC Name:
- Dioctadecyl 3,3'-thiodipropionate
- Cas Number:
- 693-36-7
- Molecular formula:
- C42H82O4S
- IUPAC Name:
- dioctadecyl 3,3'-thiodipropionate
- Details on test material:
- O=C(OCCCCCCCCCCCCCCCCCC)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC
Constituent 1
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Medium 1 : Simulated gastric fluid (pH 1.2)
Medium 2 : Simulated intestinal fluid (pH 7.5)
Medium 3 : Simulated saliva (pH 9.0)
1.1. Simulated gastric fluid (Medium 1)
700 ml of hydrochloric acid are diluted to 1000 ml with distilled water. The resulting pH value is 1.19.
1.2. Simulated intestinal fluid (Medium 2)
6.8 g of KH2PO4 are dissolved in 250 ml of water, 190 ml of 0.2 N NaOH and 400 ml of water are added. 10.0 g of pancreatin (Fluka, pig pancreas) are added, mixed, and the pH is adjusted to a value of 7.50 with 42 ml of 0.2 N NaOH. This solution is diluted with water to 1000 ml.
1.3. Simulated saliva (Medium 3)
4.2 g of sodium bicarbonate (NaHC03), 0.5 g of sodium chloride (NaCl) and 0.72 g of potassium carbonate (K2CO3) are dissolved in 1 liter of distilled water. The resulting solution has a pH value of 9.0. - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The test solutions are analysed by liquid chromatography.
Pareuneters are given below:
Pump : SPECTRA-PHYSICS 8700
Injector : SPECTRA-PHYSICS 8780 XR
Injection vol. : 10 y.1
Column : steel, 125 x 4,6 mm, packed with NUCLEOSIL C-18 5 micrometer
Column temp. : room temperature
Mobile phase :acetonitrile/tetrahydrofuran (70 + 30 parts by volume)
Flow : 1 ml/min
Detection wavelength 205 nm
Retention time: approx 7.4 min
Detection limit: 20 mg/L - Duration of treatment / exposure:
- In each case 2.00 - 2.50 mg of Irganox PS 802 are weighed into a 25 ml round bottom flask. 10 ml of the respective media (heated up to 37°C) are added. The test mixtures are kept at 37°C with stirring for at the most 240 min. The mixtures then quantitatively are transferred to 50 ml volumetric flasks using tetrahydrofuran and adjusted to the mark with tetrahydrofuran. The resulting solutions are analysed by liquid chromatography.
Results and discussion
- Details on results:
- The solubilities of the test substance in all media tested are below the detection limit of the analytical method. Therefore the hydrolysis test could not be performed. Still it was shown that the substance was stable to at least 90% of the initial concentration in all media tested (The stability tests were not performed according to GLP).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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