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Diss Factsheets
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EC number: 229-761-9 | CAS number: 6711-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-09-20 - 1999-11-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 229-761-9
- EC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 6711-48-4
- Molecular formula:
- C10H25N3
- IUPAC Name:
- (3-{[3-(dimethylamino)propyl]amino}propyl)dimethylamine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): JCZR50B (JEFFCAT ZR-50B)
- Substance type: Colorless liquid
- Physical state: Liquid
- Lot/batch No.: 160-0497
- Storage condition of test material: Room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan
- Age at study initiation: Males: 8 weeks, females: 10 weeks
- Weight at study initiation: 180 - 194 grams (dose range); 179 - 287 grams (assay)
- Fasting period before study: animals were fasted over the night before dose administration.
- Housing: Rats were group-housed prior to treatment initiation. During the study, animals were housed individually in stainless steel cages in compliance with USDA guidelines.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days prior to treatment initiation
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 26 °C
- Humidity (%): 30 - 70%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test article formulation:
The test article was prepared on a weight to volume basis with distilled water - Doses:
- 500 mg/kg, 1000 mg/kg, 1250 mg/kg, 1600 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical observations:
Recorded 1 and 4 hours (± 15 minutes) after dosing and once daily through Day 15. Signs of toxicity were recorded at least once daily as they were observed, including time of onset, degree and duration.
Weighing: Body weight: Recorded on day 1 (fasted) and on days 8 and 15 (at terminal sacrifice)
- Necropsy of survivors performed: yes: all rats were sacrificed on day 15 by CO2 asphyxiation and gross necropsies were performed, which included examination of the external body surfaces, all orifices and the thoracic, abdominal and pelvic cavities and their contents. - Statistics:
- Evaluations were made of clinical signs and body weight data. Body weights were summarized using descriptive statistics (mean and standard deviation).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 250 - < 1 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 500 and 1000 mg/kg. Three of ten and ten of ten were found dead at 1250 and 1600 mg/kg, respectively.
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- All surviving animals gained weight over the course of the study.
- Gross pathology:
- No visible lesions were observed at 500 and 1000 mg/kg or in the surviving animals at 1250 mg/kg. At 1250 mg/kg necropsy observations included stomach-distended and/or fluid-filled red; abdominal cavity - fluid-filled; intestines -fluid-filled (red) and distended; and liver - mottled and/or soft. At 1600 mg/kg necropsy observations included stomach - fluid-filled red; distended, red lesions; and intestines fluid-filled red.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based upon the results of this study, the estimated LD50 for the test article, was between 1250 and 1600 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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