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EC number: 500-240-0 | CAS number: 68958-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 26 February, 2002 to 21 March, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-Isopropylidenediphenol, polymer with 1-chloro-2,3-epoxypropane, propane-1,2-diol acrylate and succinic anhydride
- EC Number:
- 500-240-0
- EC Name:
- 4,4'-Isopropylidenediphenol, polymer with 1-chloro-2,3-epoxypropane, propane-1,2-diol acrylate and succinic anhydride
- Cas Number:
- 68958-77-0
- Molecular formula:
- UVCB, major component represented by di-functionalised BADGE (HPA-SA-BADGE-SA-HPA): C41H52O16 Other constituents present at >10%: Mono-functionalised BADGE (BADGE-SA-HPA): C35H44O14 Dimers (HPA-SA-BADGE-SA-BADGE-SA-HPA): C66H82O24
- IUPAC Name:
- 2-Propenoic acid, monoester with 1,2-propanediol, polymer with 2-(chloromethyl)oxirane, dihydro-2,5-furandione and 4,4'-(1-methylethylidene)bis[phenol]
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD rats of Sprague-Dawley origin (Hsd:Sprague-Dawley(CD))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals chosen for this study were selected from a stock supply of healthy male and female CD rat of Sprague-Dawley origin (Hsd:Sprague-Dawley(CD)) obtained from Harlan U.K. Ltd., Bicester, Oxon, England. They were in the weight range of 100 to 141 g and approx 5-7 wk of age prior to dosing (Day 1). All the rats were acclimatised to the experimental environment for a minimum period of 5 d prior to the start of the study. Rats were allocated without conscious bias to cages within the treatment groups. They were housed in groups of 3 rats of the same sex in metal cages with wire mesh floors in Building F21 Room 28. A standard laboratory rodent diet (Special Diet Services RM1(E) SQC expanded pellet) and drinking water were provided ad libitum. Access to food only was prevented overnight prior to and approx 4 h after dosing. Each batch of diet used for the study was analyzed for certain nutrients, possible contaminants and micro-organisms. Results of routine physical and chemical examination of drinking water, as conducted by the supplier are made available to Huntingdon Life Sciences Ltd. at regular intervals throughout the year. Animal room environmental controls were set to maintain temperature within the range 22 ± 3°C and relative humidity 40-70%. Any minor deviations from these ranges would not have had an adverse effect on the animals and would not affect the integrity or validity of the study. These environmental parameters were recorded daily and the permanent record archived with other departmental raw data. Lighting was controlled by means of a time switch to provide 12 h of artificial light (0600 – 1800 GMT) in each 24 h period. Each animal was identified by tail marking.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- The test substance was formulated at a concentration of either 20 or 200 mg/mL in DMSO and administered at a volume of 10 mL/kg bw. The test substance was prepared on the day of dosing. The absorption of the test substance was not determined. Chemical analysis of the homogeneity, stability and purity of the test substance was not undertaken as part of this study and remains the responsibility of the Sponsor.
- Doses:
- 200 mg/kg bw, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3/sex/dose
- Control animals:
- no
- Details on study design:
- A group of six fasted rats (three males and three females) received a single oral gavage dose of the test substance, formulated in dimethylsulphoxide (DMSO), at a dose level of 200 mg/kg bw using a glass syringe and plastic catheter. As results at this dosage indicated the acute lethal oral dose of the test substance to be greater than 200 mg/kg bw, in compliance with the guidelines, a further group of six fasted rats (three males and three females) was similarly dosed at 2000 mg/kg bw to complete the study. The day of dosing was designated Day 1. Cages of rats were checked at least twice daily for any mortalities. Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1. On subsequent days, animals were observed once in the morning and again at the end of the experimental day (with the exception of Day 15 - morning only). The nature and severity of the clinical signs and time were recorded at each observation. All animals were observed for 14 d after dosing. The bw of each rat was recorded on Days 1 (prior to dosing), 8 and 15. Individual weekly bodyweight changes and group mean bw were calculated. All animals were killed on Day 15 by carbon dioxide asphyxiation. All animals were subjected to a macroscopic examination which consisted of opening the cranial, thoracic and abdominal cavities. The macroscopic appearance of all examined organs was recorded.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths following a single oral gavage dose of the test substance to a group of six rats (three males and three females) at a dose level of either 200 or 2000 mg/kg bw.
- Clinical signs:
- other: Clinical signs of reaction to treatment comprised of abnormal gait and piloerection, seen in all animals at both dosages. In addition, increased salivation (two males and all females at 200 mg/kg bw and all females at 2000 mg/kg bw), hunched posture (all
- Gross pathology:
- No abnormalities were revealed at the macroscopic examination at study termination on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- Under the conditions of the study, the acute oral lethal dose to rats of the substance was found to be greater than 2000 mg/kg bw.
- Executive summary:
A study was performed to assess the acute oral toxicity of the test substance to the rat according to the OECD Guideline 423 and EU Method B.1 tris, in compliance with GLP. A group of six fasted rats (three males and three females) received a single oral gavage dose of the test substance, formulated in dimethylsulphoxide (DMSO), at a dose level of 200 mg/kg bw. As results at this dosage indicated the acute lethal oral dose of the test substance to be greater than 200 mg/kg bw, a further group of six fasted rats (three males and three females) was similarly dosed at 2,000 mg/kg bw. All animals were killed as scheduled and examined macroscopically on Day 15, the end of the observation period. Clinical signs of reaction to treatment comprised of abnormal gait and piloerection, seen in all animals at both dosages with increased salivation and hunched posture observed in rats at both dosages and pallor of the skin in animals at 2000 mg/kg only. Recovery of rats, as judged by external appearance and behaviour, was complete by Day 2. Animals were considered to have achieved satisfactory bodyweight gains throughout the study. No abnormalities were revealed at the macroscopic examination at study termination on Day 15. Under the conditions of the study, the acute oral LD50 of the test substance in rats was greater than 2,000 mg/kg bw (Blanchard, 2002).
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