Registration Dossier
Registration Dossier
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EC number: 267-029-0 | CAS number: 67762-64-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The results of four studies show that read-across substance, decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate is not toxic to aquatic invertebrates at its water saturation limit or water solubility limit. Therefore, by read-across, heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol pentanoate is not expected to cause acute toxicity in aquatic invertebrates. As a worst case, the lowest EL50 value was selected as the key value for chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Four studies evaluated the short-term toxicity to aquatic invertebrates of read-across substance, decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate. These studies were conducted with Daphnia magna and according to OECD Guideline 202. The first study determined an EL50 (48h) > 100 mg/L (WAF loading rate) and the results of the second study showed no immobilisation at 10000 mg/L (EL50 > 10000 mg/L, WAF loading rate). The other two studies provided an EL50 > 1000 mg/L (WAF loading rate) with an immobilisation under 50% at 1000 mg/L. In conclusion, the results of all four studies show that read-across substance, decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate is not toxic to aquatic invertebrates at its water saturation limit or water solubility limit. Therefore, by read-across, heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl) -1,3-propanediol pentanoate, which has a very similar water solubility, is not expected to cause acute toxicity in aquatic invertebrates.
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