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EC number: 248-289-4 | CAS number: 27176-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Earthworm
- Details on test organisms:
- no further information
- Study type:
- other: QSAR model
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Type of sediment:
- not specified
- Limit test:
- no
- Duration:
- 14 d
- Exposure phase:
- total exposure duration
- Hardness:
- not applicable to QSAR models
- Test temperature:
- not applicable to QSAR models
- pH:
- not applicable to QSAR models
- Dissolved oxygen:
- not applicable to QSAR models
- Salinity:
- not applicable to QSAR models
- Ammonia:
- not applicable to QSAR models
- Details on test conditions:
- 100% Benzenesulfonic acid, dodecyl-(CAS No. 27176-87-0)
SMILES : : O=S(=O)(c1ccc(cc1)CCCCCCCCCCCC)O
CHEM : Benzenesulfonic acid, dodecyl-
MOL FOR:C18 H30 O3 S1
MOL WT :326.50
Log Kow:4.78 (KowWin estimate)
Wat Sol:100 mg/L (measured) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 2 919.7 mg/kg sediment dw
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- other: QSAR model
- Details on results:
- LC50 (14-day, earthworm)= 2919.700 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 2919.700 mg/kg soil dw - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 2919.700 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 2919.700 mg/kg soil dw - Executive summary:
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 2919.700 mg/L (ppm) for freshwater sediment.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Twenty grams (wet weight) of the prepared sediment was added to clean 60 mL glass vessels followed by 30 mL of groundwater drawn from an aquifer. After 24 hours of equilibration, 10 mature Lumbriculus (ca. 15 mm in length, 8 mg dry weight) were added to each vessel. Vessels were aerated for 5 minutes every day and the overlying water replenished with distilled water every two days. Each test concentration was replicated 6 times. LAS concentrations were measured at 0 and 28 days. After 28 days the sediment was removed and all live worms counted, blotted dry, and wet weighed prior to air drying for 48 hours to a constant dry weight.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Liquid scintillation monitoring with and without HPLC.
- Vehicle:
- yes
- Details on sediment and application:
- Natural sediment was collected on Nov. 21, 1997 from ARC Study Centre, UK. The composition was 44% sand, 48% silt, and 8% clay. Total organic carbon content was 1.7%. Dried sediment samples were mixed with wet sediment for 1 hr. 10 +/-1 g samples of sediment were spiked with aliquots of LAS in dichloromethane (100 mg LAS/ml dichloromethane) and radiolabeled LAS. Samples were left overnight so the vehicle could evaporate. Unspiked sediment was used for control.
- Test organisms (species):
- Lumbriculus variegatus
- Details on test organisms:
- Lumbriculus variegatus (Oligochaete)
- Study type:
- laboratory study
- Test type:
- semi-static
- Water media type:
- freshwater
- Type of sediment:
- natural sediment
- Limit test:
- no
- Duration:
- 28 d
- Exposure phase:
- total exposure duration
- Hardness:
- 250 mg/L CaCO3
- pH:
- 8.0
- Nominal and measured concentrations:
- nominal: 50, 75, 100, 150 300 and 600 mg/kg dry weight
- Details on test conditions:
- Twenty grams (wet weight) of the prepared sediment was added to clean 60 mL glass vessels followed by 30 mL of groundwater drawn from an aquifer. After 24 hours of equilibration, 10 mature Lumbriculus (ca. 15 mm in length, 8 mg dry weight) were added to each vessel. Vessels were aerated for 5 minutes every day and the overlying water replenished with distilled water every two days. Each test concentration was replicated 6 times. LAS concentrations were measured at 0 and 28 days. After 28 days the sediment was removed and all live worms counted, blotted dry, and wet weighed prior to air drying for 48 hours to a constant dry weight.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival, reproduction, and biomass measurements at end of study
The mode of reproduction (architomy) necessitates the treatment of survival and reproduction as a single endpoint, i.e., number of organisms at test termination. - Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- >= 105 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- Survival and Growth
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 81 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- Survival and Growth
- Details on results:
- LAS half-life in aerobic sediment was approximately 20 days. This is shorter than studies conducted in the same sediment without worms (half-life of 38 days), most likely due to increased bioturbation due to worm activity.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 28-day EC50 is >= 105 mg/kg sediment dw.
- Executive summary:
This study determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with test substance at concentrations of 50, 75, 100, 150, 300, and 600 mg/kg/dry weight. 10 test organisms of species Lumbriculus variegatus were then added. Exposure lasted 28 days, at which time the organisms were observed for survival and biomass. The test substance half-life in aerobic sediment was approximately 20 days. The EC50 was >= 105 mg/kg sediment dw.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 3-day chronic study was conducted using sediment spiked with cold-material LAS.Nominal concentrations were in the range of 10 to 1,000 mg/kg/dw. The test species is an infaunal bacterial feeder with a short life cycle, so 72 hours (3 days) is considered a chronic test. The nominal concentrations were 50, 75, 100, 150, 300, 600 mg/kg/dry weight and controls. The test sediment contained 44% sand, 48% silt, and 8% clay, with 2% organic matter.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Liquid scintillation monitoring with and without HPLC.
- Vehicle:
- yes
- Details on sediment and application:
- The test sediment contained 44% sand, 48% silt, and 8% clay, with 2% organic matter.
- Test organisms (species):
- Caenorhabditis elegans
- Details on test organisms:
- The test species is an infaunal bacterial feeder with a short life cycle, so 72 hrs (3 days) is considered a chronic test.
- Study type:
- laboratory study
- Test type:
- semi-static
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Limit test:
- no
- Duration:
- 72 h
- Exposure phase:
- total exposure duration
- Hardness:
- 250 mg/L CaCO3
- pH:
- 8.0
- Nominal and measured concentrations:
- Nominal concentrations were in the range of 10-1000 mg/kg dw. The nominal concentrations were 10, 50, 100, 200, 300, 400, 500, 750 and 1000 mg/kg dw and controls.
- Details on test conditions:
- At the start of the test, ten juvenile worms of the first stage (270 ± 16 µm body length) were transferred to each test vial containing 0.75 g wet weight of spiked sediment mixed with 0.25 mL of a bacterial suspension. Five replicates were set up for each treatment, and the samples were incubated on a shaker at 20°C. After 72 hours the test was stopped by heat-killing the worms at approximately 50°C. The samples were mixed with an aqueous solution of rose Bengal to stain the worms for easier recovery. Sublethal toxicity endpoints were determined for growth based on the body length of the organisms, and fecundity by counting the number of eggs in the body of the test organism (egg production).
- Duration:
- 3 d
- Dose descriptor:
- EC10
- Effect conc.:
- 275 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 3 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 200 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- The test was regarded as valid as the fertility of the test organisms in the control was ¿ 80%.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 3-day EC10 was 275 mg/kg sediment dw based on growth rate.
- Executive summary:
This study determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with concentrations of 10, 50, 100, 200, 300, 400, 500, 750 and 1000 mg/kg dw mg/kg dw and controls. 10 test organisms of species Caenorhabditis elegans were then added. Exposure lasted 3 days, at which time the organisms were observed for survival and reproduction. The EC10 was 275 mg/kg sediment dw based on growth rate.
Referenceopen allclose all
Overview of QSARs estimations on sediment toxicity of Dodecylbenzenesulfonic acid/ Benzenesulfonic acid, dodecyl-
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)=2919.700 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 2919.700 mg/L (ppm)
There was a loss of between 15 and 78% of the LAS radioactivity over the duration
of the test, which was attributed to mineralization of LAS by the worms and microorganisms
present in the sediment (biodegradation).
Results are therefore based on the average of day 0 and day 28 measured sediment concentrations.
All results are shown in the following table.
Sediment Concentration (mg/kg dw) |
||||
Survival/Reproduction Endpoint |
NOEC |
LOEC |
EC20 |
EC50 |
Based on nominal values |
100 |
150 |
90 |
136 |
Based on measured day 0 values |
136 |
170 |
131 |
164 |
Based on mean of days 0 & 28 values |
81 |
110 |
73 |
105 |
Biomass Endpoint |
||||
Based on nominal values |
100 |
150 |
108 |
144 |
Based on measured day 0 values |
136 |
170 |
146 |
166 |
Based on mean of days 0 & 28 values |
82 |
110 |
102 |
109 |
Nominal Sediment Concentration (mg/kg dw) |
||||
Test Parameter |
NOEC |
LOEC |
EC10 |
EC30 |
Growth |
200 |
300 |
275 |
|
Fertility |
200 |
300 |
258 |
|
Egg Production |
100 |
200 |
125 |
Description of key information
The study of Comber, S.D.W.,et all 2004 determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with test substance at concentrations of 50, 75, 100, 150, 300, and 600 mg/kg/dry weight. 10 test organisms of species Lumbriculus variegatus were then added. Exposure lasted 28 days, at which time the organisms were observed for survival and biomass. The test substance half-life in aerobic sediment was approximately 20 days.
The EC50 was >= 105 mg/kg sediment dw.
The study of Comber, S.D.W.,et all 2004 determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with concentrations of 10, 50, 100, 200, 300, 400, 500, 750 and 1000 mg/kg dw mg/kg dw and controls. 10 test organisms of species Caenorhabditis elegans were then added. Exposure lasted 3 days, at which time the organisms were observed for survival and reproduction.
The EC10 was 275 mg/kg sediment dw based on growth rate.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 105 mg/kg sediment dw
- EC50 or LC50 for marine water sediment:
- 10.5 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 275 mg/kg sediment dw
- EC10, LC10 or NOEC for marine water sediment:
- 27.5 mg/kg sediment dw
Additional information
The study of Comber, S.D.W.,et all 2004 determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with test substance at concentrations of 50, 75, 100, 150, 300, and 600 mg/kg/dry weight. 10 test organisms of species Lumbriculus variegatus were then added. Exposure lasted 28 days, at which time the organisms were observed for survival and biomass. The test substance half-life in aerobic sediment was approximately 20 days.
The EC50 was >= 105 mg/kg sediment dw.
The study of Comber, S.D.W.,et all 2004 determined the toxicity to sediment dwelling organisms. Samples of natural sediment were spiked with concentrations of 10, 50, 100, 200, 300, 400, 500, 750 and 1000 mg/kg dw mg/kg dw and controls. 10 test organisms of species Caenorhabditis elegans were then added. Exposure lasted 3 days, at which time the organisms were observed for survival and reproduction.
The EC10 was 275 mg/kg sediment dw based on growth rate.
The available data for marine water sediment are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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