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Diss Factsheets
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EC number: 908-531-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 08-08-2013 to 10-09-2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- no data
- EC Number:
- 908-531-8
- Molecular formula:
- No data
- IUPAC Name:
- no data
- Test material form:
- other: Liquid
- Details on test material:
- The test item was applied undiluted.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Hannover
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats were housed individually, during acclimatization and observation periods, in polypropylene cages (30x18x19 cm) with wire mesh tops and bedding material (autoclaved wood shavings). the bedding was regularly assayed for sontaminants at the analytical laboratories of BIOAGRI Laboratorios/ Brazil, and was considered to be suitable on the basis of analytical analysis. The results are available for inspection. Clean cages were provided three times per week.
During the observation period of the animals, the room was maintained in temperature beetween 19.0 °C to 22.0 °C, with relative humidity of 34.2% to 54.9%, room ventilation set at 10 to 20 air changes oer hour, and a photoperiod of 12 hours light and 12 hours dark. Environmental control equipments were monitored and adjusted as necessary to minimize fluctuations in the animal room environment.
The food was autoclaved Nuvilab CR-1 pelleted diet type for rodents supplied by Nuvital Nutrientes Ltda. (Curitiba - PR, Brazil), which was available ad libitum throughout the study. Filtered drinking water was supplied by CAESB in water bottles for animals also ad libitum throughout the study. The food and water were regularly assayed for chemical and microbiological contaminants at the analytical laboratories. The food was assayed at BIOAGRI Laboratorio/Brazil for nutritional composition. Both, food and water, were found to be suitable on the basis of the analytical analysis and the results are available for inspection.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hour
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- Five males and five females
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No anaimal died during the study.
- Clinical signs:
- other: All males showed excoriation with ulcer from day 1 until the end of the observation period. All males showed crust from day 9 until the end of the observation period, this was of different sizes according to the grade of injury, for example, the animal 1
- Gross pathology:
- Skin microscopic examination of the animals was performed. The microscopic findings compound-related observations were: moderate irritant contact dermatitis and severe corrosve contact dermatitis.
In this study, two types of contact dermatitis were found:
- Moderate irritant contact dermatitis: it was considered when lesion affected the dermis and epidermis without reaching the muscle
- Severe corrosive contact dermatitis: it was considered when the lesion affected deep structures of the skin. The severe grade reaches up the muscle.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 value of the test item for male and female rats was estimated as being greater than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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