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Diss Factsheets
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EC number: 284-851-5 | CAS number: 84988-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
TOXICOKINETIC BEHAVIOUR
Physico-chemical properties:
Isononyl phosphate (VPXZ100) is a yellow liquid at room temperature and pressure. The substance VPXZ100 consists principally of the mono and diester: isononyl dihydrogen phosphate (CAS 27253-57-2; molecular weight 224.2 g/mol) and diisononyl hydrogen phosphate (CAS 27253-58-3; molecular weight 350.5 g/mol), respectively. It was found that 65.5% of the test item had a log10 Pow of 1.09; whereas, the remaining 34.5% had a log10 Pow in the range 3.83 to 4.28. It is most likely that these values come from the mono-ester and di-esters, respectively. The substance is not water soluble but forms stable emulsions. The vapour pressure value is 0.00013 Pa at 25 degC, which is indicative that the substance is not volatile at room temperature and pressure, therefore inhalation exposures are not a concern.
Absorption:
There are no directly measured ADME data by any route for VPXZ100.
Oral: The data on the read across analogue substance 2-ethylhexyl phosphate indicates that alkyl phosphate esters are readily available via the oral route.
Inhalation: no data, as the substance is not volatile and not expected to be inhaled.
Dermal: VPXZ100 is classified as corrosive. Damage to the skin barrier will allow this substance to absorb into the systemic circulation. Given the physicochemical properties of this substance, it is likely that skin absorption into the systemic circulation can occur. It is expected that the extent of absorption will rely heavily on the vehicle in which the substance is solubilised or emulsified.
Distribution
There are no specific data on differential distribution to organs.
Metabolism:
There is no information on the specific metabolism of isononyl phosphate. VPXZ100 may undergo hydrolysis to isononanol and phosphate. There is no evidence from in vitro genotoxicity studies to suggest that metabolism plays a role in the genotoxic properties of alkyl phosphate esters.
Excretion:
No data are available to determine the pathways or extent of excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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