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EC number: 234-679-1 | CAS number: 12023-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-02-19 until 1990-03-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Diiron titanium pentaoxide
- EC Number:
- 234-679-1
- EC Name:
- Diiron titanium pentaoxide
- Cas Number:
- 12023-27-7
- Molecular formula:
- Fe2O5Ti
- IUPAC Name:
- titanium(4+) diiron(3+) pentaoxidandiide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SAVO-Ivanovas, Kisslegg
- Sex: 1 male and 2 females
- Age at study initiation: 16 - 17 weeks
- Mean weight at study initiation: 2.84 kg
- Housing: single in cages type KK 017
- Diet: ad libitum, Altromin Standard Diet TPF 2113
- Water: ad libitum, acidified, fully demineralized water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 23 °C
- Humidity (%): 42 - 55 %
- Photoperiod (hrs dark / hrs light): 12 / 12 hours
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 hours after removal of the patches, and then daily for a period of 8 days.
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: 24 hours before treatment the backs and flanks of the animals were cautiously shaved with an electric clipper, so that the skin stayed intact.
- Type of wrap: The application sites were wrapped with polyethylene foil which was kept on place by a leather sleeve.
REMOVAL OF TEST SUBSTANCE
- Washing: After 4 hours of occlusive exposure the patches were removed and any test material left was wiped off.
OBSERVATION TIME POINTS
The rabbits were investigated for skin alterations, behaviour, and general conditions 3 hours after removal of the patches, and then daily for a period of 8 days.
SCORING SYSTEM:
- Method of calculation: Skin changes at the application site were evaluated according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No indication for skin irritation was observed at any time point.
- Other effects:
- - Other adverse local effects:
Only brown discoloration of the skin was observed on day 1 and 2 of the study due to the coloration of the test item.
- Other adverse systemic effects: All animals survived the observation period. No signs of systemic toxicity were detected. The body weight development of the treated rabbits was inconspicuous.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No skin irritating potential could be detected.
- Executive summary:
The acute skin irritation potential was investigated in three White New Zealand rabbits (1 male and 2 females) following application on the intact skin according OECD TG 404. Aliquots of neat test material (0.5 g) were moistened with water and applied to the intact skin of each rabbit for a 4-hour period under occlusive conditions. The rabbits were examined for skin reactions three hours after removal of the patches and then daily up to eight days. Skin reactions were evaluated and graded according to Draize. No signs of skin irritation were observed at any time point. Based on this study the test item is considered not to be irritating to the skin.
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