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EC number: 206-080-5 | CAS number: 299-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, similar to guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ephedrine
- EC Number:
- 206-080-5
- EC Name:
- Ephedrine
- Cas Number:
- 299-42-3
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 2-(methylamino)-1-phenylpropan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): (-)-Ephedrin, wasserhaltig
- Physical state: white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma WIGA Versuchstierezuchtanstalt, Sulzfeld
- Age at study initiation: 7 - 11 weeks
- Weight at study initiation: 185 ± 15 g
- Housing: 5 per cage Type D III or MD III, without bedding
- Diet: Herilan MRH (Firma H.Eggermann KG, Rinteln/Weser), ad libitum
- Water: tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Head-nose inhalation system
- Method of holding animals in test chamber: the animals were places in tubes and with their snouts in the inhalation chamber
- By means of an exhaust air system the pressure ratios in the inhalation system were adjusted in such a way that the amount of exhaust air was about 10% lower. This ensured that the mixture of test substance and air was not diluted with laboratory air in the breathing zones of the animals.
- System of generating particulates/aerosols: dustgenerator
- Method of particle size determination: a sample was taken after 1 hour of exposure. A pre-weighed glass fibre disk and particle filter were placed in the impactor (Stack Sampler Mark III, Andersen). A 9 L sample was taken. The contents of the preimpactor as well as on the walls of the impactor and the probed deposited were determined.
TEST ATMOSPHERE
- Brief description of analytical method used: Gravimetric determination of the concentration of the inhalation atmosphere, loadspeed of 1.25 m/s, 1 L test sample, One sample per hour.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.4 mg/L
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs and mortality were checked daily; body weights were determined prior to the study, after 7 days and at the end of the follow-up period
- Necropsy of survivors performed: yes - Statistics:
- The statistical evaluation of the study was carried out in according to the Binomialtest (Wittig, H: Mathematische Statistik 1974, page 32-35) according to the table work of BASF's data center.
The particle size determination was based on mathematical and graphical analysis methods for particle measurements (Silverman, L: Particle Size Analysis in Industrial Hygiene, 1971, page 253-259) in the Department of Industrial Hygiene and Toxicology of BASF.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.4 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality observed in all animals exposed.
- Clinical signs:
- other: No clinical signs were observed in all exposed animals.
- Body weight:
- Body weight and body weight changes were comparable between animals from the exposure group and animals from the control group.
- Gross pathology:
- No effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this test, the LC50 was determined to be >5.4 mg/L.
- Executive summary:
Ten Sprague-Dawley rats per sex were exposed in a study performed according to OECD 403 study by inhalation to 5.4 mg/L air dust aerosols of the substance for 4 hours. After an observation period of 14 days surviving animals were necropsied. No mortality or treatment related effects were observed during and after exposure. The LC50 was determined to be >5.4 mg/L air.
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