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Diss Factsheets
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EC number: 201-137-0 | CAS number: 78-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Transport and distribution of Choline hydrogen carbonate was not investigated experimentally. Important parameters of this chapter are the organic carbon-normalized sorption coefficient (Koc) and the Henry´s Law constant (HLC). Although the HLC is no mandatory requirement under REACH, it is also used in the chemical safety assessment (CSA), i.e. for the derivation of the PNECsoil using the equilibrium partitioning method (EPM). Usually, the octanol-water partition coefficient (logPow) is the first indication if a substance possesses a potential to adsorb to organic soil particles or not. However, based on the composition of Choline hydrogen carbonate, this parameter could not be determined experimentally. Furthermore, it is not possible to perform predictions with the scientifically accepted QSAR program EPIWIN by US-EPA. Due to the importance of these parameters, a read-across is intended to the structural analogue Choline chloride (CAS 67-48-1), which is considered as reliable (please refer to the detailed justification in the separate read-across statement of Chemservice S.A., 2013). Using the traditional method of the EPIWIN software KOCWIN v2.00, the Koc of Choline chloride is given as 3.736E-3 L/kg. The MCI method, which is taken more seriously into account due to improved correction factors, resulted in a value of 1.438E-3 L/kg. The adsorption depends on a variety of parameters (i.e. on the cation-exchange capacity of the sorbent) since the substance is a Quaternary Ammonium Compound (QAC). The OECD SIDS report for Choline chloride (2005) confirms that result, since therein a prediction with SRC PCKOWIN v1.66 is reported, resulting in a Koc of 2.34 (BASF AG, 2003). Thus, the read-across substance Choline chloride as well as the target substance Choline hydrogen carbonate possesses no potential to adsorb to organic matter in soil.
The HLC is predicted using the EPIWIN software HENRYWIN v3.20 for the read-across substance Choline chloride (Chemservice S.A., 2013). The Bond Method reveals a value of 2.05E-11 Pa*m3/mol at 25 °C. An “incomplete result” is given by the Group Method. These results are also taken into account for the target substance Choline hydrogen carbonate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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