Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 279-767-0 | CAS number: 81457-65-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is considered to be too large and too insoluble for systemic uptake.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Solvent Blue 67 consists of several coloured isomers which all have a molecular weight of more than 1000 g/mol. The isomers share the copper phthalocyanine core and differ in the number and position of the 3-isopropoxypropylamine substituents. The highest content of ca 65% is formed by CuPC species with four substituents having a molecular weight of 1293.04 g/mol.
The high molecular weights are above 1000 g/mol which is a generally accepted threshold for systemic uptake. In addition, the solubility in water is very low (0.008 mg/L), indicating that transport in aqueous systems is very poor. The solubility in octanol is comparatively good (2g/L), so solubility in fat is also expected to be good. Experience with low molecular weight solvent dyes shows that systemic uptake can be visualised at necropsy via colouring of the tissues. In this case, no bluish discoloration of any organ or fat tissue was observed at the end of the OECD 422 study (BASF 2013). This study was performed with doses of 100, 300 and 1000 mg/kg bw applied in form of an aqueous suspension. Also no discoloration of dam milk of pup stomach content was noted.
Considering the overall data, Solvent Blue 67 is not expected to be taken up after ingestion.
No experimental data is available for the dermal route of exposure. A default skin permeability of 10% can be assumed according to ECHA guidance if the molecular weight is higher than 500 g/mol and the log Pow is higher than 4. These criteria are fulfilled. Considering the molecular weight of > 1000 g/mol and the very poor solubility in water, skin permeability is considered to be negligible.
No experimental data is available for the inhalation route. The substance is considered to behave like an inert nuisance dust. It is not volalite and exposure could only occur via dusty material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.