Registration Dossier
Registration Dossier
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EC number: 211-629-7 | CAS number: 676-58-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The test substance Methylmagnesium chloride was examined in a respiration inhibition test with activated sludge according OECD Guideline 209. Under conditions the EC50 value of test item was determined as higher than 400 mg/L.
Key value for chemical safety assessment
Additional information
The acitvated sludge respiration inhibition test of Methylmagnesium chloride 22% in Tetrahydrofuran was conducted. Therefore test item was given to activated sludge for 3 hours. Subsequently the respiration rate of 10 minutes was measured. The respiration rate was calculated from the recorder trace as mg O2/L. In order to calculate the inhibitory effet of a test substance the repration rate was expressed as a percentage of the mean of the two control respiration rates. Corresponding to the observed concentrations (25, 50, 100, 200 and 400 mg/L Methylmagnesium chloride) the respiration depression were 2.1%, 4.3%, 11.0%, 14.5% and 19.6%. The result showed that EC50 was greater than 400 mg/L. 3,5 -Dichlorphenol was used as positive control. The calculated EC50 (3 hours) = 10.2 mg/L and was in the accepted range from 5 to 30 mg/L.
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