Registration Dossier
Registration Dossier
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EC number: 211-629-7 | CAS number: 676-58-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The test substance Methylmagnesium chloride was examined in a acute immobilisation test according OECD Guideline 202. The result indicated that the EC50(48h) for Daphnia magna was greater than 100 mg/L (highest observed testconcentration).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The purpose of this study was to evaluate the influence of the test item Methylmagnesiumchlorid on the mobility of Daphnia magna. Young organims were exposed to testwater at a range of test item concetrations for 48 h.
Atomic absorption spectrometry of test solutions was used to generate standard curve. This chromotographic genereated curve enabled to read substance concentration directly.
During the pretest the testsolution indicated no effets on Daphnia magna under nominal concentrations of 1, 10 and 100 mg/L Methylmagnesiumchlorid. Therefore it was not necessary to conduct the definitve test. However limit test with 100 mg/L testsolution was carried out for four replicates (five organisms). Each organism was less than 24 h old and more than the second generation. The inhibition of Daphnia magna was recorded after 24 h and 48 h test duration. The result indicated that the EC50(48h) for Daphnia magna was greater than 100 mg/L, which was highest observed nominal test concentration and was equivalent to 155,41 mg/L (analytical meassured result). Potassium dichromat was used as positive control. The calculated EC50 (24h) = 0.9 mg/L is in accordance with the accepted 0.6 – 2.1 mg/L range for Daphnia magna.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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