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EC number: 939-719-8 | CAS number: 5502-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study appears to follow OECD 401 with the following deviation: Sex of the animal and purity of the test substance not reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Sex of the animal and purity of the test substance not reported.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- cis-4-(isopropyl)cyclohexanemethanol
- EC Number:
- 237-539-8
- EC Name:
- cis-4-(isopropyl)cyclohexanemethanol
- Cas Number:
- 13828-37-0
- Molecular formula:
- C10H20O
- IUPAC Name:
- cis-(4-propan-2-ylcyclohexyl)methanol
- Reference substance name:
- trans-(4-propan-2-ylcyclohexyl)methanol
- Cas Number:
- 13674-19-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- trans-(4-propan-2-ylcyclohexyl)methanol
- Test material form:
- not specified
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: AMR Biological Research, Inc .
- Age at study initiation: no data
- Weight at study initiation: see table 1
- Fasting period before study:24 hours
- Housing: individually housed
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: no data
MAXIMUM DOSE VOLUME APPLIED: 10,000 mg/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: no data - Doses:
- 10,000 mg/kg bw
- No. of animals per sex per dose:
- 18
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight were recorded - Statistics:
- not required
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: no effects
- Gross pathology:
- no effects
- Other findings:
- Food consumption and water intake were normal.
Any other information on results incl. tables
Table 1. Summary of animal data from an acute oral toxicity study in rat | ||||
Animal No. | Initial weight (grams) | Final weight (grams) | Dose (g/kg) | Mortality |
5 | 340 | 349 | 10 | euthanized |
6 | 234 | 245 | 10 | euthanized |
39 | 233 | 241 | 10 | euthanized |
40 | 241 | 246 | 10 | euthanized |
41 | 226 | 242 | 10 | euthanized |
42 | 230 | 242 | 10 | euthanized |
43 | 218 | 230 | 10 | euthanized |
44 | 222 | 226 | 10 | euthanized |
45 | 226 | 227 | 10 | euthanized |
46 | 239 | 248 | 10 | euthanized |
47 | 231 | 229 | 10 | euthanized |
48 | 221 | 227 | 10 | euthanized |
49 | 218 | 230 | 10 | euthanized |
50 | 248 | 262 | 10 | euthanized |
51 | 212 | 220 | 10 | euthanized |
52 | 228 | 235 | 10 | euthanized |
53 | 237 | 245 | 10 | euthanized |
observation of toxic symptoms | |||
Animal No. | Time post admin. | Observation | Necropsy observation |
5,6, 39-53 | 15 minutes | none | - |
5,6, 39-53 | 8 hours | none | - |
5,6, 39-53 | 24 hours | none | - |
5,6, 39-53 | 48 hours | none | - |
5,6, 39-53 | 72 hours | none | - |
5,6, 39-53 | 4 days -7 days | none | - |
5,6, 39-53 | 8 days -10 days | none | - |
5,6, 39-53 | 11 days -14 days | none | none |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 oral, rat >10,000 mg/kg.
- Executive summary:
The acute toxicity of the test substance was evaluated in an oral (gavage) study in albino rats. The test compound was administered at a single dose level of 10,000 mg/kg body weight via oral gavage. The animals were observed over a period of 14 days for clinical signs of toxicity. No mortalities or toxic effects were induced by the administration of the test compound at this dose level. Therefore, the oral LD50 of the substance was considered to be greater than 10,000 mg/kg body weight in rats.
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