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EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The irritation potential of dipotassium heptafluorotantalate was determined in both the skin and eyes.
SKIN IRRITATION:
According to the key study (Pößernecker, 1992) performed to GLP and in accordance with standardised guideline EPA OPP 81-5, the test material was shown to be not irritating to the skin.
EYE IRRITATION:
According to the key study (Blanchard, 2001) performed to GLP and in accordance with standardised guidelines; OECD 405, EU Method B.5 and EPA OPPTS 870.2400, the test material was shown to be highly irritating to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
SKIN IRRITATION
The key study (Pößernecker, 1992) is a GLP compliant study performed in accordance to the standardised guideline EPS OPP 81-5. The study was performed to a good standard in line with sound scientific principles and was assigned a reliability score of 1, using the principles set out in Klimisch (1977). The robust study exposed six rabbits to a single application of 0.5g of the test material for four hours, which were then observed for the following 6 days. Neither erythema nor oedema was seen in any of the tests animals over the observation period.
EYE IRRITATION
The key study (Blanchard, 2001) is a robust, GLP compliant study performed in accordance with the following standardised guidelines: OECD 405, EU Method B.5 and EPA OPPTS 870.2400. This was assigned a reliability score of 1, using the principles for assessing data reliability set out in Klimisch (1977). The test results are deemed to be an accurate assessment of the effects of the test material. Approximately 100 mg of the test material was applied directly into the eye of one rabbit, using the other eye as a contrlateral control; the rabbit was observed once at 1 hour post application and for the second time at 24 hours post application. The ocular reaction observed was so severe that no other animals were tested and the test animal was sacrificed one day after dosing. Elicited corneal opacification, iridial inflammation and considerable conjunctival irritation were observed. Under the conditions of the study, the test material caused elicited corneal opacification, iridial inflammation and considerable conjunctival irritation. The test material therefore requires classification as an eye irritant.
RESPIRATORY IRRITATION
Under the conditions of the acute inhalation toxicity study (Weniger, 2006) exposure to the test material, over a period of 4 hours,lead to mortalities and local destruction in the lower airways and alveoli, with some reactive inflammation. It is assumed that this effect was a result of aqueous solutions of K2TaF7, at physiological temperatures, yielding the complex ion TaF72-, a Lewis acid which imparts a pH of 2 to the solution, which is capable of causing serious damage to the tissues of the respiratory system.
Justification for selection of skin irritation / corrosion endpoint:
Only one study is avaialble.
Justification for selection of eye irritation endpoint:
Only one study is avaialble.
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
SKIN IRRITATION
The skin irritation study indicates that the test material has no effect on the skin and therefore does not require classification under Regulation 1272/2008.
EYE IRRITATION
The eye irritation study indicates that the test material is highly irritating and of serious risk to the eyes. Under Regulation 1272/2008, the test material requires classification as "Category 1" with the hazard statement "H318: Causes serious eye damage."
RESPIRATORY IRRITATION
Tissue dmamage seen in the acute inhalation toxicity study indicates that the test material is irritating to the respiratory system. Under Regulation 1272/2008, the test material required classification as "STOT SE Category 2" with the hazard statement "H335: May cause respiratory irritation."
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