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Diss Factsheets
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EC number: 943-065-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read Across Information is available from a structural analogue that has been tested in a GLP compliant OECD TG 423 assay. The LD50 in rats after single oral administration exceeds 2000 mg/kg bw/day.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read Across Justification - Acute Oral Toxicity for Art. 132039 (RGA 565 100)
Type of Read Across: one - to -one
Chemical Similarity
The Dossier Compound, Boron doped barium europium strontium silicate, shows a data gap for Acute Oral Toxicity. However, information for this endpoint is available for the structural analogue, Barium europium strontium silicate.
Both compounds share the same silicate core structure and differ only in the Boron present in small amounts in the silicate of the target molecule with the data gap. There are no additional structural features of toxicological concern introduced in the traget molecule that are not present in the source molecule yet. Overall the high chemical similarity supports the read across from the target to the query molecule.
Physicochemical Similarity
The solubility of both compounds has been determined by measuring the concentration of the individual cations present in the silicate by means of ICP OES of the water extracts. It turned out that cationic ingredients like barium and strontium dissolve in water. They are moderately soluble. The cationic ingredient europium is not soluble in water. This result is confirmed by several supporting studies. Comparing the solubility profile yields a high similarity regarding the different cations.
Compound | Study | Ba | Sr | Eu |
Ba Eu Sr SiO4 | Key | 0,24 | 0,8 | 0,038 |
Ba Eu Sr SiO4 | Supp.001 | 0,54 | 0,6 | 0,07 |
Ba Eu Sr SiO4 | Supp.002 | 0,87 | 0,49 | 0,12 |
(B) Ba Eu Sr SiO4 | Key.001 | 0,528 | 0,488 | 0,05 |
(B) Ba Eu Sr SiO4 | Supp.005 | 0,38 | 0,47 | 0,05 |
(B) Ba Eu Sr SiO4 | Supp.003 | 0,287 | 0,524 | 0,05 |
(B) Ba Eu Sr SiO4 | Supp.004 | 0,829 | 0,411 | 0,05 |
The boron containing silicate yields an additional small fraction of boron of 6.6 mg/L (cf. water solubility, Sup_Water solubility_132008.003).
The pH of compounds is in the same range, i.e. 11-11.5.
Overall the relevant physicochemical data water solobility and pH show a high similarity supporting the read across from the target to the query molecule.
Biological similarity
Both compounds have been characterized for skin irritation in vitro in GLP compliant assays following the OECD TG 439 protocol employing the Reconstructed Human Epidermis Test by measuring cell-viabilities of cultivated human keratinocytes after topical application of test or control substance in a MTT assay. In this assay both compounds have been evaluated to be negative.Read Across
The acute toxicity assay in the rat after single oral administration performed for the structural analogue, Barium europium strontium silicate, shows that the oral LD50 value in rats exceeds 2000 mg/kg bw/d.This information is used for read across from the source molecule to the target molecule in order fill the data gap for acute oral toxicity. This read across is based on the high structural similarity, the absence of additional structural alerts in the target molecule, the almost identical physicochemical parameters relevant for exposure in biological tests and the absence of local irritation in skin models.
The high similarity demonstrated for chemical structure, physicochemical properties and biological response justifies using the information available for the source molecule to fill the data gap of the target molecule.
Justification for classification or non-classification
no need for classification, as LD 50 > 2000 mg/kg bw /d
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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