Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs., compds. with isopropanolamine

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Because of the shorter than normal study duration and smaller than standard number of fish per concentration, the reliability of the absolute values cannot be assessed. However, the study is considered reliable for the trends in the data because the homologues were tested under identical conditions.

Data source

Reference

Reference Type:

publication

Title:

Reduction of aquatic toxicity of linear alkylbenzene sulfonate (LAS) by biodegradation.

Author:

Kimerle, R.A. and Swisher, R.D.

Year:

1977

Bibliographic source:

Water Research 11:31-37.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: EPA-660/3-75-009 1975. Method for acute toxicity tests with fish, macroinvertebrates and amphibians.

Principles of method if other than guideline:

Acute toxicity tests were conducted on high molecular weight LAS, individual pure homologues, non-linear LAS components (dialkyl tetralin or indane sulfonates, DTIS), and model biodegradation intermediates (sulfophenylundecane, SOU) in order to determine whether biodegradation decreases toxicity. Toxicity tests were conducted in 5 L of 100 mg/L hardness water using 5 fathead minnows per concentration.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts

EC Number:

270-115-0

EC Name:

Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts

Cas Number:

68411-30-3

Molecular formula:

Not available - not a single isomer - see remarks

IUPAC Name:

Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts

Details on test material:

1) High molecular weight LAS: Average chain length = 13.3; C11 1%, C12 8%, C13 52%, C14 39%
2) Individual LAS homologues of C10, C11, C12, C13, and C14
3) Nonlinear LAS components (DTIS)
4) Model biodegradation intermediates

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Pimephales promelas

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Post exposure observation period:

open-system

Test conditions

Hardness:

5 L of 100 mg/L hardness water

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

1.7 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

mortality (fish)

Any other information on results incl. tables

Sublethal observations / clinical signs:

		Fathead minnow LC50 (mg/L)
	Average chain length	24 hour	48 hour
High molecular weight LAS	13.3	1.9	1.7
Individual homologues LAS
C10	10	48.0	43.0
C11	11	17.0	16.0
C12	12	4.7	4.7
C13	13	1.7	0.4
C14	14	0.6	0.4
Nonlinear LAS components (DTIS)
C10	10	87.0 ± 7.5	86.1 ± 15.0
C12	12	24.8 ± 5.8	21.5 ± 5.5
C14	14	8.1 ± 5.1	5.3 ± 3.9
Model biodegradation intermediates
C4 (SØ Butyrate)	4	~10,000	~10,000
C5 (SØ Valerate)	5	~10,000	~10,000
C11 (SØU)	11	85.9 ± 5.1*	76.6 ± 12.4*

*Subsequent repurification of this sample yielded a product with the same isomeric composition but with LC₅₀ values over 1000 mg/L for fatheads.