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EC number: 618-460-1 | CAS number: 9010-89-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The pH-dependent hydrolysis of Polyesterol 90212 in water was determined in a GLP-compliant study performed according to OECD Guideline 111 (see chapter 4 of the IUCLID). In a first tier, solutions of the test substance in H2O with a concentration of 1553 mg/L were adjusted to pH values of 4.0, 7.0 and 9.0. The resulting solutions were stored in sealed and purged vials at 50°C for 5 days. Samples were taken at the beginning and after 5 days and the content of the test item was determined using HPLC/UVD. After 5 days 33.01%, 70.50%, and 100% of the test substance were hydrolyzed at pH 4, 7, and 9, respectively.
A substance which is structurally related to Polyesterol 90212,
namely the cyclic ester of adipic acid with diethyleneglycol (CAS
6607-34-7), was tested regarding its stability in rat plasma in vitro.
Before investigating enzymatic hydrolysis in rat plasma, it was checked
whether the test substance is non-enzymatically hydrolyzed in phosphate
buffer (pH 7.1) and hydrochloric acid (pH 3.0). No hydrolysis was
detected after 4 hours incubation in the two respective buffers.
To determine enzymatic hydrolysis of the test substance, nominal
concentrations of 1068 and 5335µg/ml were freshly prepared in rat
plasma. Beginning hydrolysis could already be observed 1 hour after
starting the test at both concentrations. After 4 hours, 18.18% of the
test substance were hydrolyzed at 1068µg/ml, whereas 90.53% were
hydrolyzed at 5335µg/ml. It was anticipated that enzymatic hydrolysis is
more pronounced at higher concentrations due to saturation of plasma
protein binding the test substance and a consequently higher
concentration of free substance in plasma which is available for
enzymatic hydrolysis.
The data above indicate that Polyesterol 90212 is hydrolytically instable. Enzymatic hydrolysis is more pronounced at higher concentrations of the test substance, whereas non-enzymatic hydrolysis is more pronounced at higher pH values. The observation that the test substance is almost completely hydrolyzed in plasma after 4 hours indicates that the systemically available species and will be the hydrolysis products, namely adipic acid and ethylene glycol. It can thus be anticipated that the effects of the test substance on human health can be derived from data for the hydrolysis products. In accordance with REACH Annex XI, section 1.5, read-across to the hydrolysis products is considered appropriate to cover the endpoints which require repeated dose toxicity studies under REACH Tier 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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