Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 278-115-2 | CAS number: 75199-13-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 September to 28 September, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Remarks:
- dechlorinated tap water (sodium thiosulphate)
- Details on test solutions:
- - Method of preparation: direct dispersion in water with the aid of shielded propeller-stirrers
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- - Common name: Rainbow trout
- Length: 5.8 ± 0.7 cm
- Weight: 3.17 ± 1.00 g
- Loading: 0.79 g bw/l
- Supplier: Trafalgar nurseries, Sailsbury, UK
- Medication: none.
- Acclimation: not specified
- Feeding during acclimation and test: not specified - Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post exposure observation period
- Hardness:
- Approximately 50 mg/l as CaCO3
- Test temperature:
- 14 ± 1 °C
- Nominal and measured concentrations:
- Measured concentrations are not specified. Nominal concentrations are used for all evaluations.
- Details on test conditions:
- TEST SYSTEM
- Test vessels: 40 l
- Aeration: yes
- Media renewal: daily
- No. of organisms per vessel: 10
- No. of vessels per concentration: 2 replicates
- No. of vessels per control: 1
TEST CONCENTRATIONS
- Range finding study: yes (1.0, 10 and 100 mg/l)
- Results used to determine the conditions for the definitive study: no mortality in range finding study up to 72 hours, therefore, highest concentration used for the definitive study
- Test concentrations in definitive study: 100 mg/Ll (limit test) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The range finding study was terminated after 72 hours up to a test item concentration of 100 mg/l as sufficient data had been gathered to determine the no effect level (i.e. 100 mg/l) and allow initiation of the definitive study.
- Sublethal observations / clinical signs:
Results from the range finding study.
Concentration (mg/L) Cumulative Mortality (initial population = 3) 24 h 48 h 72 h 96 h control 0 0 0 -* 1.0 0 0 0 - 10 0 0 0 - 100 0 0 0 - Results from the definitive study.
Concentration (mg/L) Cumulative Mortality (initial population = 10) 24 h 48 h 72 h 96 h control 0 0 0 0 100 R1 0 0 0 0 100 R2 0 0 0 0 R1 = first replicate
R2 = second replicate
- Conclusions:
- The 96 hour LC50 of the test item was greater than 100 mg/l (nominal).
- Executive summary:
The short-term toxicity of the test item to fish was evaluated in an experimental study according to a method comparable to OECD guideline 203 limit test. In a dose range finding study, groups of 3 fish were exposed to either 0, 1.0, 10 or 100 mg/l test item in dechlorinated tap water (sodium thiosulphate) for 72 hours, after which time no mortality was observed and the study was terminated. Based on the absence of mortality, the highest concentration of 100 mg/l test item was chosen for the definitive study.
In the definitive study, two replicate groups of 10 fish were exposed to the test item (100 mg/l) for 96 hours, as well as an additional control group of 10 fish in parallel, and checked for mortality every 24 hours. All findings are based on the nominal test item concentrations. No mortality was observed in the control or either replicate group after 96 hours, therefore, the 96 hour LC50 of the test item was greater than 100 mg/l.
Reference
Description of key information
LC50 (96 h, Oncorhynchus mykiss) > 100 mg/l (nominal)
Key value for chemical safety assessment
Additional information
The short-term toxicity of the substance to fish was examined in a 96 hour test, run as limit test using Oncorhynchus mykiss. The concentration which leads to 50 % mortality of O. mykiss (LC50) after 96 hours of exposure is greater than 100 mg/l, reported as nominal concentration due to poor water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.