Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-745-1 | CAS number: 68910-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Organolignite is a UVCB substance with no available analytical method to detect it in biological fluids or tissues. Despite this limitation, sufficient physicochemical data, acute hazard data, and repeat-dose inhalation toxicity data have been developed that can be used to assess organolignite's absorption, distribution, metabolism, and elimination. Physiochemical properties indicate that organolignite would not be absorbed from biological membranes, including the gastrointestinal tract. A repeated dose inhalation toxicity study indicates that organolignite is not distributed beyond the lung.
Key value for chemical safety assessment
Additional information
Organolignite is a UVCB substance with no available analytical method to detect it in biological fluids or tissues. Despite this limitation, sufficient physicochemical data, acute hazard data, and repeat-dose inhalation toxicity data have been developed that can be used to assess organolignite's absorption, distribution, metabolism, and elimination. We refer to this process as the substance's toxicokinetic (TK) profile or TK. There is no human data regarding organolignite's TK.
Physicochemical Properties
Inhalation is the primary human exposure route, however, the physical size of the particles that comprise bulk organolignite suggest little of it is respirable in the human lung. For example, particle size distribution data shows that less than 3% of organolignite is at or below 10 microns in diameter. On the molecular level, organolignite has a molecular weight > 20000 Da, which suggests that the substance will not readily cross biological membranes, including the gastrointestinal tract. This observation is strongly supported by organolignite's chemical properties (i.e., water solubility of 0.054 mg/L; log Kowof 3.6). The results of several acute toxicity studies, discussed below, further support this conclusion.
Acute Toxicity Studies
Acute dermal study data in laboratory animals demonstrates that organolignite is not an irritant/corrosive, it does not elicit an allergic response, and it does not cause any local or systemic toxicity when applied to the skin. It is generally recognized that exposure via the inhalation route leads to greater absorption of a substance when compared with exposure via the dermal route. An acute inhalation toxicity study in rats revealed no apparent toxicity by this route of exposure at a concentration of approximately 2000 mg/m3 (2.0 mg/L).
Repeat-Dose Toxicity Studies
A combined repeated dose toxicity study with a reproduction/developmental toxicity screening test showed no adverse effects, including no reproductive or developmental effects, even at the high dose exposure level of 300 mg/m3 (0.3 mg/L). Male rats in this study were exposed to organolignite for approximately 4 weeks and female rats were exposed for approximately 6 weeks. At necropsy, dark discoloration of the lungs was noted in males and females treated at the mid (50 mg/m3) and high dose. Other necropsy findings at the high dose included pale foci on the lungs, dark discoloration of the bronchial lymph nodes and dark discoloration of the mediastinal lymph nodes; both sets of lymph nodes are associated with the lung. Lung and lymph node discoloration is consistent with clearance because organolignite is dark in color. Based on histopathological examinations of key organs (e.g., liver, brain, heart, kidney, mammary gland, ovary, pancreas, skeletal muscle, spleen, and GI tract associated lymphoid tissue), there is no evidence that organolignite is distributed beyond the lung when exposure occurs via inhalation.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.