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EC number: 248-372-5 | CAS number: 27253-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-05-14 to 2018-05-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Two vessels will be set up in a parallel design, each vessel will be sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Two vessels will be set up in a parallel design, each vessel will be sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2016-05-31
- Type of method:
- flask method
- Specific details on test material used for the study:
- Storage conditions: Keep container tightly closed, in a dry place at room temperature.
- Water solubility:
- 19.1 g/L
- Conc. based on:
- element
- Remarks:
- lithium
- Loading of aqueous phase:
- 1 007 other: Lithium neodecanoate
- Incubation duration:
- >= 9 - <= 11 d
- Temp.:
- 20.9 °C
- pH:
- >= 10.5 - <= 11.2
- Remarks on result:
- other: S.D.: ± 1.2 g Li/L
- Key result
- Water solubility:
- 482 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- lithium neodecanoate
- Loading of aqueous phase:
- 1 007 g/L
- Incubation duration:
- >= 9 - <= 11 d
- Temp.:
- 20.9 °C
- pH:
- >= 10.5 - <= 11.2
- Remarks on result:
- other: S:D: ± 30 g/L
- Details on results:
- - Mean temperature during the test was 20.9 ± 0.3 °C (necessary range 20.0 ± 1.0 °C)
- the pH value of solutions containing the test item was in the range of 10.5 – 11.2
- the pH value in method blanks was in the range of 6.5 - 7.4
- Turbidity in samples from test (day 9) was always <1 NTU indicating that filtered solutions did not contain any undissolved material
- Analytical measurements:
Slight lithium concentrations in method blanks were detected (up to 14 µg/L), but far below the concentrations in test samples (19.1 g/L). Therefore, no background subtraction was performed. The concentrations in method blanks might be due to the ubiquitous lithium.
The calculated variations / changes between sampling points were less than 15 % for the days 9, 10 and 11. Furthermore, no increase of the lithium concentrations were observed. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 1.006 and 1.008 kg/L test substance in vessel 1 and 2, respectively), a solubility equilibrium was reached at day 9, 10, 11 of testing. The mean measured amount of dissolved lithium on day 9, 10 and 11 at a test temperature of 20.9 ± 0.3 °C is 19.1 ± 1.2 g/L (determined as dissolved lithium, separated by centrifugation from undissolved test item). This corresponds to a water solubility of dissolved lithium neodecanoate of 482 ± 30 g/L, calculated on a lithium content of 3.964 % and a test substance purity of 100 % (w/w). Solution pH in samples containing the test item remained at 10.5 – 11.2 while the pH in method blanks ranged from 6.5 - 7.4.
Reference
ICP-OES measurement of test samples and method blanks with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery.
date |
Calibration [µg/L] – lowest and highest calibration point |
Chosen wavelength [nm] |
LOD [µg/L] |
LOQ [µg/L] |
correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
May 24, 2018; measurement of test samples (9 d and 10 d) and method blanks |
50 – 1000 (total of 12 calibration points, 11 used + blank) |
Li: 670.783 |
Li: 0.04 |
Li: 0.11 |
Li: 0.99951 |
Li: 18 |
Li: 94.4 |
May 25, 2018; measurement of test samples (11 d) and method blanks | 50 – 1000 (total of 11 calibration points, 11 used + blank) | Li: 670.783 | Li: 0.04 |
Li: 0.12 |
Li:0.99985 |
Li: 13 |
Li: 100 |
Recovery / validation data lithium of measurement series
Element Li |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
May 24, 2018 |
||||
Quality control standard (Roth) 100 µg/L |
106 |
1 |
4 |
4 |
Quality control standard (Roth) 500 µg/L |
102 |
<1 |
4 |
4 |
Recalibration standard 250 µg/L |
99.7 |
0.3 |
4 |
4 |
Recalibration standard 750 µg/L# |
109 |
5 |
4 |
3 |
May 25, 2018 |
||||
Quality control standard (Roth) 100 µg/L |
103 |
0.2 |
3 |
3 |
Quality control standard (Roth) 500 µg/L |
102 |
0.5 |
3 |
3 |
Recalibration standard 250 µg/L |
97.6 |
0.2 |
3 |
3 |
Recalibration standard 750 µg/L |
99.7 |
0.9 |
3 |
3 |
Fortification of measurement series
element |
measured concentration [µg/L] |
calculated level after addition [µg/L] |
recovery [µg/L] / [%] | |
May 24, 2018 |
||||
Li |
638 |
608 |
592/ 97.4 |
|
Li |
609 |
842 |
849/ 101 |
|
May 25, 2018 | ||||
Li | 697 | 299 | 291/ 97.2 |
The determination of the water solubility of lithium neodecanoate is based on mean lithium concentrations of sampling days (9, 10, 11 day) and a mean lithium amount of 3.964 % in the test item. The amount of dissolved lithium neodecanoate was calculated with a test item purity of 100 % (w/w) according to test substance data sheet as follows:
Mean Li
concentrations
Vessel 1: 19.1±
1.1 g/L Li
Vessel 2: 19.1 ± 1.4 g/L Li
Mean: 19.1 ± 1.2 g/L Li
Based on a test item purity of 100 % the water solubility of lithium neodecanoate is:
Mean of concentration x 100 % / 3.964 %:
Vessel 1: 481±
28 g/L test item
Vessel 2: 482 ± 36 g/L test item
Mean: 482 ± 30 g/L test item
Description of key information
According to OECD Guideline 105 (1995) and EU Method 440/2008 A.6, the test item lithium neodecanoate has a water solubility of 482 ± 30 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 482 g/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 1.006 and 1.008 kg/L test substance in vessel 1 and 2, respectively), a solubility equilibrium was reached at day 9, 10, 11 of testing. The mean measured amount of dissolved lithium on day 9, 10 and 11 at a test temperature of 20.9 ± 0.3 °C is 19.1 ± 1.2 g/L (determined as dissolved lithium, separated by centrifugation from undissolved test item). This corresponds to a water solubility of dissolved lithium neodecanoate of 482 ± 30 g/L, calculated on a lithium content of 3.964 % and a test substance purity of 100 % (w/w). Solution pH in samples containing the test item remained at 10.5 – 11.2 while the pH in method blanks ranged from 6.5 - 7.4.
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