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EC number: 242-358-2 | CAS number: 18479-49-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.09.2014 - 26.11.2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,7-dimethyloct-1-en-3-ol
- EC Number:
- 242-358-2
- EC Name:
- 3,7-dimethyloct-1-en-3-ol
- Cas Number:
- 18479-49-7
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- aerobic activated sludge from a wastewater treatment plant (ARA Ergolz II, Füllinsdorf, Switzerland) treating predominantly domestic wastewater
- Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 298 other: mg O2/L test solution
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The test design and test system are consistent with the testing guidelines and should provide a rational basis to assess the ready biodegradability of the test item under aerobic conditions.
The study was performed with aerobic activated sludge from a wastewater treatment plant (ARA Ergolz II, Füllinsdorf, Switzerland) treating predominantly domestic wastewater. The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated.
Based on this ratio, calculated amounts of wet sludge were suspended in test water (see below) to obtain a concentration equivalent to 4 g dry material per liter. During the holding period of two days prior to use, the sludge was aerated at room temperature. Prior to use, the sludge was first thoroughly mixed and then diluted with test water to a concentration of 1 g per liter (dry weight basis). Based on the determined dry weight of this diluted activated sludge, defined amounts were added to test water to obtain a final concentration of 30 mg dry material per liter.
Test Water
The test water was prepared according to the testing guidelines. Analytical grade salts were dissolved in purified water to obtain the following stock solutions:
1) KH2PO4 8.50 g/L
K2HPO4 21.75 g/L
Na2HPO4 x 2H2O 33.40 g/L
NH4Cl 0.50 g/L
The pH of this solution was 7.4.
2) MgSO4 x 7H2O 22.50 g/L
3) CaCl2 x 2H2O 36.40 g/L
4) FeCl3 x 6H2O 0.25 g/L, stabilized with one drop of concentrated HCl per liter.
To obtain the final test water, 10 mL of stock solution No. 1 and 1 mL each of stock solution Nos. 2, 3 and 4 were combined and made up to 1000 mL with purified water. The pH was adjusted from 7.9 to 7.4 with a diluted hydrochloric acid solution.
Test Concentrations
Approximately 25 mg test item was added to the designated test flasks with test water. No emulsifiers or solvents were used.
The reference item sodium benzoate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control. A stock solution containing 2.5 g sodium benzoate per liter test water was prepared by completely dissolving 250 mg sodium benzoate in 100 mL test water. From this stock solution, 10 mL aliquots were added to the corresponding test flasks containing test water.
Finally, activated sludge was added to each test flask. The final test volume was 250 mL per test flask.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- not applicable
- Test performance:
- The results are considered to be valid since the following criteria are met:
- The degradation rates of the replicate test flasks containing the test item, test water and inoculum deviated by less than 20% at the end of the 10-day window and at the end of the test (criterion: not more than 20% deviation at the end of the 10-day window, at the time the plateau is reached or at the end of the test, as appropriate).
- The percentage degradation of the reference item reached the level for ready biodegradability by Day 3 (criterion: at least 60% of ThOD in a 10-day window by
Day 14 for the reference item).
- The mean oxygen demand of the inoculum control (medium and inoculum) was 8 mg O2/L within 28 days (criterion: normally 20-30 mg O2/L, but not greater than
60 mg O2/L).
- The pH was in the range 7.5 – 7.9 in all flasks after 28 days of exposure (criterion: not outside the range 6.0 – 8.5).
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 61
- Sampling time:
- 28 d
- Remarks on result:
- other: Indication of inherent biodegradability
- Details on results:
- The percent biodegradation of the test item was calculated based on the theoretical oxygen demand (ThOD) of 2.97 mg O2/mg test item.
The biochemical oxygen demand (BOD) of 3,7-dimethyloct-1-en-3-ol in the test media significantly increased from Exposure Day 6 until Day 9. Afterwards the increase of the BOD was less intense, but continued during the whole test period. At the end the test, on Exposure Day 28, the mean biodegradation of 3,7-dimethyloct-1-en-3-ol amounted to 61% of the ThOD. A plateau of the biodegradation curve was not reached.
BOD5 / COD results
- Results with reference substance:
- In the toxicity control, containing both 3,7-dimethyloct-1-en-3-ol and the reference item sodium benzoate, the biodegradation amounted to 43% and 64% by Exposure Day 14 and 28, respectively. Therefore, the test item had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration of 100 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- The test item 3,7-dimethyloct-1-en-3-ol was found to be not readily biodegradable in a manometric respirometry test over 28 days according to the OECD Guideline for Testing of Chemicals No. 301 F, Commission Regulation (EC) No 440/2008, C.4-D and the US EPA Draft Ecological Effects Test Guidelines OPPTS 835.3110 (Paragraph (q)).
However, according to paragraph 36 of the Revised Introduction to the OECD Guidelines for Testing of Chemicals, Section 3 (2006), the obtained result of 61% biodegradation within 28 days, can be used to indicate inherent biodegradability of 3,7-dimethyloct-1-en-3-ol. - Executive summary:
The test item 3,7-dimethyloct-1-en-3-ol was investigated for its ready biodegradability in a manometric respirometry test over 28 days according to the OECD Guideline for Testing of Chemicals No. 301 F, Commission Regulation (EC) No 440/2008, C.4-D and the US EPA Draft Ecological Effects Test Guidelines OPPTS 835.3110 (Paragraph (q)).
The percent biodegradation of the test item was calculated based on the theoretical oxygen demand (ThOD) of 2.97 mg O2/mg test item.
The biochemical oxygen demand (BOD) of 3,7-dimethyloct-1-en-3-ol in the test media continuously increased from Exposure Day 6 until the test end. The mean biodegradation of 3,7-dimethyloct-1-en-3-ol amounted to 61% of the ThOD at the end of the test, on Exposure Day 28, and a plateau of the biodegradation curve was not reached.
Since, the pass level for ready biodegradability, i.e. biodegradation of at least 60% of the ThOD in a 10-day window within the 28-day period of the test, was not reached, the test item was found to be not readily biodegradable. However, the obtained result of 61% biodegradation within 28 days, can be used to indicate inherent biodegradability of 3,7-dimethyloct-1-en-3-ol.
In the toxicity control, containing both 3,7-dimethyloct-1-en-3-ol and the reference item sodium benzoate, the biodegradation amounted to 43% and 64% by Exposure Day 14 and 28, respectively. Therefore, the test item had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration of 100 mg/L.
In the procedure controls, the reference item sodium benzoate was degraded by an average of 61% and 82% by Exposure Day 3 and 14, respectively and reached 84% by the end of the test (Day 28), thus confirming suitability of the activated sludge.
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