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Diss Factsheets
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EC number: 230-525-2 | CAS number: 7173-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Mar, 1990 - 27 Apr, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- No analytical dose verification
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- semi-static
- Limit test:
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.97 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.49 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
96 hour-LC50 = 0.97 mg/l, with 95% confidence limits of 0.8-1.2 mg/L. The highest concentration causing no mortality (no observed effect concentration, NOEC) after 96 hours amounted to 0.56 mg/L. whereas 100% mortality was produced within 2 hours at 1.8 mg/L.
There were no effects observed on the behaviour of the fish during the exposure period, except for the fish at 1.0 mg/L
which showed reduced activity after 6 hours exposure.- Validity criteria fulfilled:
- yes
- Conclusions:
- All validity criteria can be considered as fulfilled. The 96 h LC50 of the test substance in fish was 0.49 mg/L.
- Executive summary:
Short term toxicity to fish was evaluated according to OECD Guideline 203 and EU Method C.1 under GLP conditions. Seven fish per concentration were exposed to 0.18, 0.32, 0.56, 1.0 or 1.8 mg/L of acommercial product containing 50% DDAC for 96 h. The test was conducted under semi-static conditions, with the test solution being renewed after 48 h. No analytical dose verification was performed and all values mentioned are nominal. The highest concentration causing no mortality (NOEC) after 96 h was 0.56 mg/L whereas 100% mortality occurred within 2 h at 1.8 mg/L. There were no effects on behavior during the exposure period, except for the fish at 1.0 mg/L which showed reduced activity after 6 h. The 96 h LC50 of the test substance was 0.49 mg a.i./L. All validity criteria can be considered as fulfilled.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No analytical dose verification
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 22°C
- pH:
- 6.8 - 7.1
- Dissolved oxygen:
- 7.93 - 8.05
- Nominal and measured concentrations:
- 0, 0.25, 0.50, 1.00, 2.50 and 5.00 mg/L (nominal)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- ca. 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h LC50 of the test substance for Brachydanio rerio was 0.7 mg/L. The 96h NOEC was 0.5 mg/L and the 96h LC100 was 1.0 mg/L.
- Executive summary:
A study was conducted to determine the acute toxicity of DDAC to Brachydanio rerio according to OECD guideline 203. Fish were exposed to a commercial product (purity not stated) under static conditions for 96 hours. Mortality and lethargy were observed. The 96h LC50 of the test substance was 0.7 mg/L. The 96h NOEC was 0.5 mg/L and the 96h LC100 was 1.0 mg/L.
Referenceopen allclose all
Description of key information
- Key value from Registrant: 96 h LC50 = 0.49 mg a.i./L
- Key value from DDAC biocides assessment report for Product Type 8 (June 2015): 96 h LC50 = 0.19 mg a.i./L
In the present report, the 96 h LC50 of 0.19 mg a.i./L was selected as key value, in line with the methodology followed in the DDAC biocides assessment report for Product Type 8.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.19 mg/L
Additional information
Short term toxicity to Zebra fish (Danio rerio) was evaluated according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. Seven fish per concentration were exposed to 0.18, 0.32, 0.56, 1.0 or 1.8 mg/L of a commercial product containing 50% test substance for 96 h. The test was conducted under semi-static conditions, with the test solution being renewed after 48 h. No analytical dose verification was performed and all values mentioned are nominal. The highest concentration causing no mortality (NOEC) after 96 h was 0.56 mg/L whereas 100% mortality occurred within 2 h at 1.8 mg/L. There were no effects on behaviour during the exposure period, except for the fish at 1.0 mg/L which showed reduced activity after 6 h. The 96 h LC50 of the test substance was 0.49 mg a.i./L. All validity criteria can be considered as fulfilled (Akzo Nobel, 1990).
Another study was conducted to determine the acute toxicity of the test substance to Zebra fish (Danio rerio) according to OECD Guideline 203. Fish were exposed to a commercial product (purity not stated) containing the test substance under static conditions for 96 h. Mortality and lethargy were observed. The 96 h LC50 was 0.7 mg/L. The 96 h NOEC was 0.5 mg/L and the 96 h LC100 was 1.0 mg/L (Akzo Nobel, 1990).
The DDAC biocides assessment report for Product Type 8 conducted under Directive 98/8/EC (evaluating Competent Authority: Italy, June 2015, attached in Section 13 of the IUCLID dataset), reported an additional study on DDAC, apart from the above EQC studies. This study resulted in a 96 h LC50 = 0.19 mg a.i./L. The RMS considered the lower value from this study as the endpoint for the product authorisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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