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EC number: 229-929-1 | CAS number: 6843-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Genotoxicity in vitro:
Ames test (OECD 471, GLP): positive in strain TA 1535 without metabolic
activation
Ames test (OECD 471, GLP): negative in all strains including TA 1535
Ames test (similar to OECD 471): negative in all strains including TA
1535
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Genetic toxicity in vitro:
Three reliable Ames assays are available for assessment of genetic toxicity of dimethoxydiphenylsilane.
In an Ames assay, conducted according to OECD TG 471 (adopted 1997) and in compliance with GLP (SafePharm Laboratories Ltd, 2002), Salmonella typhimurium strains TA 1535, TA 1537, TA 98 and TA 100 as well as E. coli WP2 were treated with the registered substance up to 5000 µg/plate dimethoxydiphenylsilane (CAS 6843-66-9) in the absence and presence of a metabolic activation system. No increase in revertants/plate was detected at any concentration up to cytotoxic concentration, with metabolic activation. Without metabolic activation also no increase in revertants/plate was observed in all strains except TA 1535. Incubation of TA 1535 led to a reproducible increase in revertants/plate by the factor of 2-3 over several concentrations, although a clear dose-response effect was not shown, as a plateau was reached very early. Cytotoxicity was not observed. Appropriate solvent and positive controls were included and gave expected results.
In a second reliable Ames assay, also conducted according OECD TG 471 (adopted 1983) and in compliance with GLP (Hüls AG, 1995e) Salmonella typhimurium strains TA 1535, TA 1537, TA 98 and TA 100 were treated with up to 5000 µg/plate dimethoxydiphenylsilane (CAS 6843-66-9) in the absence and presence of a metabolic activation system. No increase in revertants/plate was detected at any concentration up to cytotoxic concentration, with or without metabolic activation, in either the initial plate incorporation assay or the repeat pre-incubation test. Cytotoxicity was observed after incubation with 5000 μg/plate in strains S. typhimurium TA 1535 and S. typhimurium TA 1537. Appropriate solvent and positive controls were included and gave expected results.
Similar results were observed in a third Ames test, conducted similarly to OECD TG 471 (Dow Corning Corporation, 1977). Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98 and TA 100 treated with up to 500 µg/plate dimethoxydiphenylsilane (CAS 6843-66-9) in the absence and presence of a metabolic activation system. No increase in revertants/plate was detected at any concentration, with and without metabolic activation.
A positive result was found in one out of the three Ames tests with the registered substance. In the Ames test with the positive result, only Salmonella typhimurium strain TA 1535 without metabolic activation, resulted in a stitistically significant increase in the number of revertants, but a clear dose-response effect was not observed as a plateau was reached very early. Also, no effects were found in the other two reliable studies. Thus, it is concluded that dimethoxydiphenylsilane (CAS 6843-66-9) is negative for mutagenicity to bacteria under the applied test conditions.
Justification for classification or non-classification
The available data on genetic toxicity in bacteria of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC. According to Annex VII no further testing is required.
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