Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-698-5 | CAS number: 2499-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetics study was not available on n-hexyl acrylate. A read-across is proposed between N-hexyl acrylate and N-Butyl acrylate for repeated dose systemic and reproductive/developmental effects. This read-across is justified in attachements per relevant endpoint study record. Based on the chemical and physical state, a low absorption is expected after oral route, dermal route or inhalation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).
Both substances share similar physical chemical properties:
|
N-hexyl acrylate |
N-butyl acrylate |
Molecular Weight |
156.22 g/mol |
128.17 g/mol |
Melting Temperature |
-48 °C |
-64.6 °C |
Boiling Temperature |
190°C at 1013.25 hPa |
147 °C at 1013.25 hPa |
Density |
0.882 g/cm3at 20°C |
0.9 g/cm3at 20°C |
Water Solubility |
57.4 mg/L at 20°C |
1.7 g/L at 20°C |
Vapor Pressure |
130 Pa at 20 ± 1°C |
500 Pa at 22.2°C |
Partition coefficient |
4.2 at 40°C
|
2.38 at 25°C |
ABSORPTION
Based on the physicochemical characteristics of n-hexyl acrylate, a higher log Kow equal to 4.2 and a low molecular weight, a low oral absorption is expected. The assumption of a low oral absorption is confirmed by data on acute oral toxicity where no mortalities were observed at doses > 2,000 mg/kg (LD50 22.9 g/kg bw in rats).
Dermal absorption of n-hexyl acrylate is expected to be slowed due to binding to skin of the acrylate group and the low water solubility. This is supported by the low toxicity observed in acute dermal testing (LD50 = 4.98 g/kg). However n-hexyl acrylate is a moderate skin sensitizer based on the guinea pig maximization test.
According to the value of vapor pressure (130 Pa at 20°C) both substances are considered to be slightly volatile. Low absorption by inhalation of N-hexyl acrylate is expected at the maximum attainable concentration due to the low values of vapor pressure, log Kow and water solubility.
DISTRIBUTION/METABOLISM/EXCRETION
As a small molecule, a wide distribution of n-hexyl acrylate is expected. No specific test data was found on metabolism of n-hexyl acrylate.
Evidence from other types of acrylates suggests that hydrolysis of the ester bond is likely to occur, producing acrylic acid which is further biotransformed to carbon dioxide and the corresponding alcohol. Alternative bio-elimination pathways include conjugation with Glutathione (GSH) by Glutathione-S-transferase. Detoxification by hydrolysis is supported by studies in which the toxicity of various acrylate esters was enhanced following the inhibition of carboxyl esterase by tri(ortho-toyl)phosphate (TOTP) (Silver et al. 1978; Silver 1981). Additionally, following inhalation or at high exposure levels, carboxylesterase-mediated hydrolysis may be saturated and residual intact ester may reach systemic circulation and influence systemic toxicity through binding with macromolecules.
The major routes of excretion for both substances from the systemic circulation are the urine (due to the low molecular weight) and the exhaled air (of the hydrolysis products).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.