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EC number: 217-370-6 | CAS number: 1825-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- H:
- -2.77 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: log Kaw
- H:
- 4.2 Pa m³/mol
- Temp.:
- 25 °C
- H:
- 2 Pa m³/mol
- Temp.:
- 12 °C
- Conclusions:
- A log Kaw value of -2.77± 0.10 at 25.0°C was determined for trimethylsilanol. This is equivalent to a dimensional Henry’s Law Constant of 2.0 Pa m³/mol at 12°C (4.2 Pa m³/mol at 25°C).
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26/05/2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- Principles of method if other than guideline:
- This study used a custom-made glass apparatus which allowed the establishment of an octanol/air/water equilibrium for simultaneous determination of Kaw, Koa and Kow. The apparatus consisted of two air-tight syringes with an air sampling port in one syringe and a water sampling port on the other. The air phase in both syringes was connected through a valve during the equilibrium, but the valve was closed during sampling. Samples were collected from the air and water phases from 1 to 90 hours to establish attainment of equilibrium in the system. Air samples were collected using a cryogenic gas trap. Water samples were extracted using a two-step procedure.
- H:
- -2.77 dimensionless
- Temp.:
- 25 °C
- H:
- 4.2 Pa m³/mol
- Temp.:
- 25 °C
- H:
- 2 Pa m³/mol
- Temp.:
- 12 °C
- Conclusions:
- A log Kaw value of -2.77± 0.10 at 25.0°C was determined for trimethylsilanol. This is equivalent to a dimensional Henry’s Law Constant of 2.0 Pa m³/mol at 12°C (4.2 Pa m³/mol at 25°C).
Referenceopen allclose all
Average log Kaw was found to be -2.77 ± 0.10 for TMS at 25.0 °C.
This is equivalent to a dimensional Henry's law constant value of 4.2 Pa m³ mol-1.
Average log Kaw was found to be -2.77 ± 0.10 for TMS at 25.0°C.
This is equivalent to a dimensional Henry's law constant value of 4.2 Pa m3 mol-1.
Description of key information
Henry’s Law Constant: 2.0 Pa m³/mol at 12°C (4.2 Pa m³/mol at 25°C).
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 2
- at the temperature of:
- 12 °C
Additional information
Ethoxytrimethylsilane (CAS 1825-62-3) hydrolyses rapidly in water to trimethylsilanol and ethanol (half-life = 2.2 min at 25 °C and pH 7). Due to the very fast hydrolysis of the parent substance the assessment of volatility is only relevant for the hydrolysis products. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read-across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read-across from the hydrolysis product trimethylsilanol (CAS 1066-40-6) has been applied to support the environmental hazard assessment of ethoxytrimethylsilane. Details on the read across justification can be found in the overall justification for grouping of substances attached in IUCLID Section 13.
This study used a custom-made glass apparatus which allowed the establishment of an octanol/air/water equilibrium for simultaneous determination of Kaw, Koa and Kow. The apparatus consisted of two air-tight syringes with an air sampling port in one syringe and a water sampling port on the other. The air phase in both syringes was connected through a valve during the equilibrium, but the valve was closed during sampling. Samples were collected from the air and water phases from 1 to 90 h to establish attainment of equilibrium in the system. Air samples were collected using a cryogenic gas trap. Water samples were extracted using a two-step procedure. A log Kaw value of -2.77± 0.10 at 25.0°C was determined for trimethylsilanol. This is equivalent to a dimensional Henry’s Law Constant of 2.0 Pa m³/mol at 12°C (4.2 Pa m³/mol at 25°C). This value will be used for the environmental risk assessment.
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