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Diss Factsheets
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EC number: 232-019-7 | CAS number: 7783-66-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published study, acceptable with restrictions (only a brief summary of methods and results was published).
Data source
Reference
- Reference Type:
- publication
- Title:
- The comparative skin irritant properties of dichlorethylsulphide ("mustard gas") and other agents
- Author:
- Hanzlik P.J. and Tarr J.
- Year:
- 1 919
- Bibliographic source:
- J. Pharm. Exp. Therap., 1919, Vol. XIV, no. 3, pp 221-228
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study predates OECD/EU/EPA test guidelines. The publication does not present substance specific information. Compounds were applied to animal (non-rodent, mostly dog) or human skin, by direct application, diluted in a suitable solvent or by a vapour method. Time of appearance of hyperemia and other changes was noted and the extension and severity of all changes was studied quantitatively (results were expressed in terms of square centimetres of area involved). No data are given on the duration of the exposure and observation periods.
- GLP compliance:
- no
- Remarks:
- Study predated GLP guidelines
Test material
- Reference substance name:
- Iodine pentafluoride
- EC Number:
- 232-019-7
- EC Name:
- Iodine pentafluoride
- Cas Number:
- 7783-66-6
- Molecular formula:
- F5I
- IUPAC Name:
- pentafluoro-λ⁵-iodane
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): iodine pentafluoride
Constituent 1
Test animals
- Species:
- other: non-rodent
- Details on test animals or test system and environmental conditions:
- The publication does not indicate on which animal species the substance was tested. The following general information is given: Dogs were used principally owing to the limited amount of human material and the large number of compounds studied. Human skin was used as much as permissible and possible. Monkeys, a horse and the cock's comb and wattles were also used. Rodents were not used.
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: Animals: shaving and washing. Humans: no data.
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Compounds were also tested as dilutions in a suitable solvent but no substance-specific information is given.
- Controls:
- not specified
- Amount / concentration applied:
- The publication does not present substance specific information. The following general information is given:
- Amount applied to animal skin (5 cm2 area): 0.005 cc. (from a pipette graduated to deliver 0.005 to 0.05 cc.) or 5 mg of the compound equivalent to the application of 0.001 cc. (or 1 mg) per cm2 of skin.
- On human skin the tests were made by touching a small area with a fine glass rod dipped into the irritant. This method could not be used quantitatively.
- Vapours of volatile compounds were tested by two qualitative methods (vapor concentration not known) and a quantitative method (with determined vapor concentration). - Observation period:
- The time of appearance of hyperemia and all other changes was noted, and the extension and severity of all changes was studied quantitatively as much as possible from day to day and the results expressed in terms of square centimeters of area involved. Dichlorethylsulphide was chosen as the standard by which the irritant properties of other compounds were judged.
Results and discussion
In vivo
Results
- Remarks on result:
- other: Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.
- Irritant / corrosive response data:
- Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.
Applicant's summary and conclusion
- Conclusions:
- Iodine pentafluoride was found to be a severe irritant in an in vivo study predating OECD and GLP guidelines.
- Executive summary:
The skin irritant properties of various compounds were tested in vivo in studies predating OECD and GLP guidelines. The available publication does not present substance specific information, only a brief summary of methods and results was published. The compounds were applied to animal (non-rodent, mostly dog) or human skin, by direct application, diluted in a suitable solvent or by a vapor method. Time of appearance of hyperemia and other changes was noted and the extension and severity of all changes was studied quantitatively (results were expresseed in terms of square centimeters of area involved). No data are given on the duration of the exposure and observation periods. Iodine pentafluoride was found to be a severe irritant as indicated by hyperemia, swelling and edema, ulceration, necrosis, etc., on dog's skin and similar changes together with vesication on human skin.
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