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EC number: 244-216-5 | CAS number: 21112-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-04-25 to 2019-05-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- OECD Guideline for the Testing of Chemicals – 111 Hydrolysis as a Function of pH
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test Item Name: Vetimoss
Chemical Name: 2-tert-butyl-1,4-dimethoxybenzene
Batch/Lot Number: A180118C
CAS Number: 21112-37-8
Appearance: Clear, pale yellow liquid
Expiry Date: 06 June 2019
Purity: 98 %
Storage condition: Protected from humidity (tight closed container) and under inert gas - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Test vessels: 10 – 10 tubes with Test Media (at all pH levels) were spiked with the Spiking Stock Solution. 5 of them were processed immediately to determine the initial concentration of the test item and the other 5 tubes were incubated at 50°C for 5 days and, after the incubation period, all the tubes were processed and measured.
- Control: 4 – 4 control tubes were also prepared (Test Media without spiking) to check the potential interfering components from the buffer. 2 of them were processed immediately to determine the initial concentrations of the test item and the other 2 tubes were incubated at 50°C for 5 days and, after the incubation period, both control tubes were processed and measured. - Details on test conditions:
- SOLUTIONS, MIXTURES
- Diluent: n-Heptane was used as Diluent.
- Extraction Solvent: n-Heptane was used as Extraction Solvent.
- Test Media: Aqueous buffers at pH 4, 7 and 9 were used as Test Media.
- Stock Solution of Test Item: Approx. 15 mg Test Item was weighed with 0.01 mg precision into 10 mL volumetric flask and filled up with Diluent. The solution was mixed well by hand. The concentration of the test item was approx. 1.5 mg/mL.
- Working Solution: The Stock Solution of Test Item was diluted to 0.1 mg/mL with Diluent.
- Stock Solution of Internal Standard: Approx. 15 mg Internal Standard was weighted with 0.01 mg precision into 5 mL volumetric flask and filled up with Diluent. The solution was mixed well by hand. The concentrations of the test item was approx. 3 mg/mL.
- Calibration Solutions: The Stock Solution of Test Item and the Working Solution were diluted to the 0.01 – 0.15 mg/L range and constant amount of Stock Solution of Internal Standard was added. Calibration solutions were injected in duplicate.
- Spiking Stock Solution: Approx. 50 mg Test Item was weighted with 0.01 mg precision into 5 mL volumetric flask and filled up with Tetrahydrofuran. The solution was mixed well by hand. The concentration of the test item was approx. 10 mg/mL.
- Preparation of Test Solutions: 50 mL Test Media was spiked with 50 µL Spiking Stock Solution and mixed well by hand.
- Analytical Sample Preparation: 50 mL aliquot of Test Solution was extracted with 1 mL Extraction Solvent (50x enhancement). 100 µL extract was mixed with 50 µL Stock Solution of Internal Standard and 850 µL Diluent.
- Temperature: The Test Solutions were kept between 50.1 – 50.4°C. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.408 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.744 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.789 mg/L
- Number of replicates:
- 10 – 10 tubes with Test Media (at all pH levels) were spiked with the Spiking Stock Solution.
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- 4 – 4 control tubes of test media without spiking
- Preliminary study:
- The Vetimoss test item is hydrolytcally stable in pH 4 – 9 range, with recoveries of 95.1-99.6% after 5 days at 50°C.
- Transformation products:
- not measured
- % Recovery:
- 99.3
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 99.6
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 95.1
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- The Vetimoss is hydrolytically stable at 50°C.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Vetimoss is hydrolytically stable at 50°C.
- Executive summary:
The potential for Vetimoss to hydrolyse at 3 different pHs was examined in a study undertaken in accordance with OECD 111. Vetimoss is hydrolytically stable at pH 4, 7 and 9 at 50°C.
Reference
Stability of the test item after 5 days
pH |
cTestSol (mg/L) |
Stability (%) |
|
Day-0 |
Day-5 |
||
4 |
10.408 |
10.332 |
99.3 |
7 |
10.744 |
10.704 |
99.6 |
9 |
10.789 |
10.263 |
95.1 |
Measured initial concentrations
Sample |
cTheroretical (mg/L) |
pH |
cTestSol (mg/L) |
cAverage (mg/L) |
% of cTheor |
RSD (%) |
191-HYD-001 |
0 |
4 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-002 |
0 |
4 |
<LOQ |
|||
191-HYD-003 |
10.070 |
4 |
10.619 |
10.408 |
103.4 |
2.5 |
191-HYD-004 |
10.070 |
4 |
10.080 |
|||
191-HYD-005 |
10.070 |
4 |
10.378 |
|||
191-HYD-006 |
10.070 |
4 |
10.247 |
|||
191-HYD-007 |
10.070 |
4 |
10.717 |
|||
191-HYD-008 |
0 |
7 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-009 |
0 |
7 |
<LOQ |
|||
191-HYD-010 |
10.070 |
7 |
10.662 |
10.744 |
106.7 |
1.1 |
191-HYD-011 |
10.070 |
7 |
10.741 |
|||
191-HYD-012 |
10.070 |
7 |
10.616 |
|||
191-HYD-013 |
10.070 |
7 |
10.789 |
|||
191-HYD-014 |
10.070 |
7 |
10.914 |
|||
191-HYD-015 |
0 |
9 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-016 |
0 |
9 |
<LOQ |
|||
191-HYD-017 |
10.070 |
9 |
10.746 |
10.789 |
107.1 |
1.3 |
191-HYD-018 |
10.070 |
9 |
10.858 |
|||
191-HYD-019 |
10.070 |
9 |
10.594 |
|||
191-HYD-020 |
10.070 |
9 |
10.982 |
|||
191-HYD-021 |
10.070 |
9 |
10.767 |
Measured concentrations after 5 days
Sample |
cTheroretical (mg/L) |
pH |
cTestSol (mg/L) |
cAverage (mg/L) |
% of cTheor |
RSD (%) |
191-HYD-022 |
0 |
4 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-023 |
0 |
4 |
<LOQ |
|||
191-HYD-024 |
10.070 |
4 |
10.597 |
10.332 |
102.6 |
6.3 |
191-HYD-025 |
10.070 |
4 |
10.531 |
|||
191-HYD-026 |
10.070 |
4 |
10.670 |
|||
191-HYD-027 |
10.070 |
4 |
10.693 |
|||
191-HYD-028 |
10.070 |
4 |
9.167 |
|||
191-HYD-029 |
0 |
7 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-030 |
0 |
7 |
<LOQ |
|||
191-HYD-031 |
10.070 |
7 |
10.749 |
10.704 |
106.3 |
0.6 |
191-HYD-032 |
10.070 |
7 |
10.740 |
|||
191-HYD-033 |
10.070 |
7 |
10.585 |
|||
191-HYD-034 |
10.070 |
7 |
10.713 |
|||
191-HYD-035 |
10.070 |
7 |
10.733 |
|||
191-HYD-036 |
0 |
9 |
<LOQ |
<LOQ |
N/A |
N/A |
191-HYD-037 |
0 |
9 |
<LOQ |
|||
191-HYD-038 |
10.070 |
9 |
10.879 |
10.263 |
101.9 |
5.9 |
191-HYD-039 |
10.070 |
9 |
10.260 |
|||
191-HYD-040 |
10.070 |
9 |
10.333 |
|||
191-HYD-041 |
10.070 |
9 |
10.582 |
|||
191-HYD-042 |
10.070 |
9 |
9.262 |
Description of key information
The potential for Vetimoss to hydrolyse at 3 different pHs was examined in a study undertaken in accordance with OECD 111. Vetimoss is hydrolytically stable at pH 4, 7 and 9 at 50°C.
Key value for chemical safety assessment
Additional information
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