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EC number: 269-824-8 | CAS number: 68334-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Results published in a peer-reviewed scientific publication and in the EU Risk Assessment DODMAC (EU, 2002).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Radiolabelling:
- yes
- Vehicle:
- no
- Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- Bluegill, Lepomis macrochirus, were obtained from commercial fish hatcheries and averaged 1.3 g in weight (from 1.2 to 1.7 g) and 38 mm in length (from 23 to 60 mm). Fish were acclimated for 14 to 30 d prior to use in water having physical and chemical characteristics similar to those of the water used in the tests. Fish were fed trout chow daily during acclimation and during tesing, but were not fed 24 to 48 h prior to testing.
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 49 d
- Total depuration duration:
- > 21 - < 35 d
- Hardness:
- 14-38 mg/L CaCO3 (Town river)
315-348 mg/L CaCO3 (Well water) - pH:
- 6.4-7.7 (Town river)
7.1-7.9 (Well water) - TOC:
- TOC: no data
Suspended matter: Town river 2-84 mg/L, Well water 0 mg/L - Details on test conditions:
- Bluegill were exposed to nominal 20 µg/L concentrations of 14C-labeled DTDMAC in aerated, carbon-filtered well water and to 23 µg/L in Town River water under continuous flow conditions. No solvent was used in the two tests. The 14C-DTDMAC equilibrated in the test waters for 13 d prior to introducing the fish into the 30-liter glass test chambers. The 115 fish in the two exposure aquaria and the 50 fish in the two control tanks were fed trout chow daily during testing.
- Nominal and measured concentrations:
- Nominal concentration tested = 20 µg/L
- Type:
- BCF
- Value:
- 256 L/kg
- Basis:
- non-edible fraction
- Time of plateau:
- 14 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:20 µg/L - Well water
- Type:
- BCF
- Value:
- 94 L/kg
- Basis:
- non-edible fraction
- Time of plateau:
- 49 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:23 µg/L - River water
- Type:
- BCF
- Value:
- 32 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 14 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:20 µg/L - Well water
- Type:
- BCF
- Value:
- 13 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 49 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:23 µg/L - River water
- Elimination:
- yes
- Parameter:
- other: 93% of the test item was depurated after 14d
- Depuration time (DT):
- 14 d
- Conclusions:
- The BCF values for bluegill were very low in river water (13 L/kg wwt), and slightly higher in well water (32 L/kg wwt). The BCF river water of 13 L/kg wwt was used in the EU Risk Assessment DODMAC (EU, 2002). The relatively higher values in well water, whether based on residues in inedible tissue or in whole body, indicate the reduced bioavailability of the surfactants in surface water.
- Executive summary:
Lepomis macrochiruswas exposed to14C-DTDMAC for 49 days in a continuous flow-through system in river water and laboratory water with mean concentrations in the test period of 18 µg/L and 16 µg/L respectively (no solvent carrier, Lewis & Wee, 1983). The river water was sampled at Town River, Massachusetts, and contained 2-84 mg/L suspended solids, 0.04-0.59 mg/L (methylene blue active substances) MBAS and 10-15 mg/l disulfine blue active substances (DBAS) (pH = 6.4-7.7; total hardness = 14-38 mg/L CaCO3). In river water,BCFs of 13 L/kg in the whole bodyand 94 in the inedible tissue (viscera) were estimated based on measured concentrations. When laboratory water was used, the respective BCFs were 32 and 256 L/kg. In both waters DTDMAC did not concentrate to a significant degree in edible tissue (BCF of the fillets < 5 L/kg). In a depuration phase in well water 93% of the accumulated radioactivity was eliminated from the inedible tissues after 14 days.
Overall, these results demonstrated that testing cationic surfactants under more realistic conditions (in river water) give lower bioavailibility compared to studies using laboratory water.
Based on these test data, it can be concluded thta DTDMAC is not bioconcentrating in fish.
Reference
Bioconcentration of DTDMAC by bluegill varied with the tissue analyzed and with the dilution water used in the test. Bluegill exposed to a mean-measured concentration of 20 (±
1 SD = 10) µg/L DTDMAC in well water and to an average 23 (k 12) µg/L DTDMAC in Town River water did not concentrate the surfactant in edible tissue (fillets) to any significant degree. On the other hand, residues were measured in inedible tissue (viscera) of fish in both test waters.
Mean BCF in inedible tissues of fish in well water and river water were 256 and 94, respectively. These BCF values were based on
the ratio of the mean14C residues in fish to the mean-measured concentrations in the waters over days 14 to 49 of the exposure period (time of steady state). During this time period, the residues averaged 4,100 (well water) and 1,700 (river water) µg/kg, and the mean DTDMAC levels in the well and river waters were 16 and 18 µg/L, respectively. Bluegill, after being transferred to well water containing no DTDMAC, eliminated 93% of the residues in inedible tissues after 14 d.
Whole body BCF were estimated to be 32 (well water) and 13 (river water). Based on estimated residues in whole body and in inedible tissues, bluegill concentrated DTDMAC in well water about three times more than in river water.
Description of key information
Key value for chemical safety assessment
- BCF (aquatic species):
- 13 L/kg ww
Additional information
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