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EC number: 602-791-3 | CAS number: 122584-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. No information on purity of the substance.
- GLP compliance:
- not specified
- Type of method:
- thermal analysis
- Melting / freezing pt.:
- ca. 165 °C
- Conclusions:
- The melting point of the T002078 is ca. 165 deg C.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-01-12 to 2017-04-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Batch n°: I15EB1917
- Analytical purity: 98.9%
- Expiration date: 2017-09-07
- Storage condition: at room temperature - Key result
- Melting / freezing pt.:
- 162.3 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Remarks:
- A black and beige molten residue remained after the preliminary and main test, indicating reaction and/or decomposition.
- Decomp. temp.:
- >= 250
- Conclusions:
- The melting temperature of JNJ-28645409-AAA (T002078) was determined at 162.3°C (435.4K) using DSC.
Referenceopen allclose all
It is the result of either thermal analysis in DSC apparatus on mg scale and/or other DTA equipment (Differentrial Temperature Analysis ) on gram scale.
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly at 275°C. At 332°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: white, brown grey). The change of the colour indicated reaction and/or decomposition of the test item.
Main tests
In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min was obtained and showed an endothermic peak between 150°C and 200°C. The extrapolated onset temperature of the peak was 162.3°C. The effect was most likely obtained due to melting. A second endothermic peak was observed between 250°C and 325°C due to reaction and/or decomposition of the test item. After the experiment, a black molten residue remained. To investigate the melting peak between 150°C and 200°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 162.27°C. The melting temperature of T002078 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 162.3°C (523K).
Description of key information
In a GLP study according to OECD guideline 102, EU method A.1 and EPA OPPTS 830.7200 (Klimisch 1, Brekelmans, 2017) the melting point of T002078 was determined to be 162.3°C (435.4K).
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 162.3 °C
Additional information
A supporting study (Janssen Pharmaceutica Process Safety Center, 1996) with insufficient documentation, and therefore assigned as Klimisch 4 study, concluded that the melting temperature of T002078 is about 165°C, which is in line with the result of the key study by Brekelmans (2017).
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