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EC number: 274-159-1 | CAS number: 69852-45-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute toxicity of Aradur 1019 via oral and dermal routes have been determined. Both studies were carried out before published methods, such as OECD guidelines, were available. The methodology used is equivalent to the current guidelines in all cases.
The results are reported:
Acute oral LD50 2284 mg/kg bw
Acute dermal LD50 >4500 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Healthy random bred rats of the Tif: RAIf (SPF) strain raised on our premises were used for these experiments. They were kept at a room temperature of 22 + 1° C, at a relative humidity of 55 + 5 % and on a 10 hours light cycle day. They received ad libitum rat food - NAFAG, Gossau SG - and water. Prior to treatment the animals were adapted to our laboratories for a minimum of 4 days and the initial body weight ranged from 160 to 180 grams.
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10, 20, 30, 50% of formulation - Doses:
- 1000, 2150, 2780, 3170, 3590 and 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 284 mg/kg bw
- 95% CL:
- >= 2 026 - <= 2 576
- Mortality:
- Deaths occured after 24 hours at 2150 mg/kg dosage. 100% mortality was seen at 4649 mg/kg after 24 hours
- Clinical signs:
- Within 2 hours after treatment the rats in all dosage groups showed sedation, dyspnoea, exophthalmos, curved position and ruffled fur. Sedation became more accentuated as the dose was increased. The surviving animals recovered within 8 to 9 days.
- Body weight:
- Not recorded
- Gross pathology:
- No substance related gross organ changes were seen
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute oral LD50 of TK 12271 in rats of both sexes observed over a period of 14 days is 2284 (2026-2576) mg/kg. The test material has therefore a slight acute toxicity to the rat by this route of administration.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 284 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: A method for determining the dermal toxicity of pesticides. British Journal of Industrial Medicine, Vol 26, page 59-64, 1969
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Batch number Sdg. 807701
- Species:
- rabbit
- Strain:
- other: Tvanovas, 7964 Kisslegg/Allggsu
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 to 3 kg
- Housing: Wire cages, 10 hours a day light cycle
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 10%
- Photoperiod (hrs dark / hrs light): 14 hrs dark / 10 hrs light
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: Adhesive, elastic
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with lukewarm water
- Time after start of exposure: 24 hours after treatment
TEST MATERIAL
- Concentration (if solution): 1, 2, 4 and 6 ml/kg body weight
- Duration of exposure:
- 24 hours
- Doses:
- 1, 2, 4 and 6 ml/kg body weight
1000, 2000, 4000 and 6000 mg/kg - No. of animals per sex per dose:
- 3
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Day 1, 7 and 14
- Necropsy of survivors performed: yes/no Yes
- Other examinations performed: Sedation, dyspnoea, dacryorrhoea, chromydacryorrhoea, rinorrhea, epistaxis, salivations, ruffled fur, pallor, cyanosis, diarrhoea, body position (ventral), body position (lateral), body position (curved), ataxia, tirmus, tremor, tonic cllonic muscle spasms, convulsions. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 100% at top dose (6000 mg/kg)
- Clinical signs:
- After 24 hours all animals at doses 1000 and 2000 mg/kg showed signs of sedation, ruffled fur and had a curved body position. They recovered from sedation after 11 days, ruffled fur after 8 days and curved body position after 5 days.
At the 4000 mg/kg dose level the same symptoms were seen at 2 hours, along with ataxia and tremor at day 2, which were gone on day4. - Body weight:
- Body weight remained consistent throughout the study
- Gross pathology:
- No substance related gross organ changes were seen.
- Other findings:
- The material was shown to cause severe skin irritation
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal LD50 of TK 12271 in rabbits of both sexes observed over a period of 14 days is approximately 4 500 mg/kg. The test material has therefore a slight acute toxicity to the rabbit by this route of application.*
Severe skin irritation did occur. - Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Sex:
- male/female
- Details on dermal exposure:
- Healthy random bred rats of the Tif: RAIf (SPF) strain raised on our premises were used for these experiments. They were kept at a room temperature of 22 + 1° C, at a relative humidity of 55 + 5 % and on a 10 hours light cycle day. They received ad libitum rat food - NAFAG, Gossau SG - and water. Prior to treatment the animals were adapted to our laboratories for a minimum of 4 days and the initial body weight ranged from 180 to 200 grams.
- Duration of exposure:
- 24 hours
- Doses:
- 3590 and 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No weights were recorded
- Necropsy of survivors performed: yes
- Other examinations performed: Within 24 hours after treatment the rats in all dosage groups showed dyspnoea, exophthalmQs, curved position and ruffled fur. No local skin irritation was seen. The animals recovered from systemic symptoms within 11 to 13 days. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No substance related mortaility was observed
- Clinical signs:
- Within 24 hours after treatment the rats in all dosage groups showed dyspnoea, exophthalmQs, curved position and ruffled fur. No local skin irritation was seen. The animals recovered from systemic symptoms within 11 to 13 days.
- Body weight:
- Not recorded
- Gross pathology:
- No substance related gross organ changes were seen
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal LD50 of TK 12271 in rats of both sexes observed over a period of 14 days is greater than 4600 mg/kg, The test material has therefore practically no acute toxicity to the rat by this route of administration.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Batch no. : Sdg. 807701
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Healthy random bred rats of the Tif: RAIf (SPF) strain (8 to 9 weeks old) raised on the premises were used for these experiments. They were kept at a room temperature of 22 + 2° C, at a relative humidity of 55 + 10 % and on a 10 hours light cycle day. They received ad libitum rat food - NAFAG, Gossau SG - and water. Prior to treatment the animals were adapted to our laboratories for a minimum of 4 days.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- During the treatment and observation period the rats were housed individually in Macroion cages (type 2). Approximately 24 hours before treatment an area on the back of the rats of approximately 60 square cm was shaved with an electric clipper. For treatment the test material was evenly dispersed on the skin with a syringe and was covered with an occlusive dressing which was fastened around the trunk with an adhesive elastic bandage. After 24 hours the dressing was removed, the skin was cleaned with lukewarm water and the reaction of the skin was appraised
- Duration of exposure:
- 24 hours
- Doses:
- 2000, 3000 and 4000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Logit model
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- The animals recovered from systemic symptoms within 7 to 8 days. They were submitted to a necropsy at the end of the observation period.
- Body weight:
- Body weights remained consistent throughout
- Gross pathology:
- No substance related gross organ changes were seen.
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal LD50 of TK 12271 in rats of both sexes observed over a period of 14 days is greater than 4000 mg/kg, The test material has therefore practically no acute toxicity to the rat by this route of application. *Skin irritation did occur.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 500 mg/kg bw
Additional information
Justification for classification or non-classification
Results for acute oral and dermal toxicity give LD50 results that are above the upper limit for classification according to CLP. However, according to GHS it would be assessed for classification as category 5.
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