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EC number: 500-345-1 | CAS number: 157627-95-7 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan - 10 Mar 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- Revised 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): collected from Harrogate South sewage treatment works (North Yorkshire, UK).
- Concentration of sludge: 4.3 g/L.suspended solids - Duration of test (contact time):
- 28 d
- Initial conc.:
- 15 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: acc. to guideline
- pH: 7.21 - 7.68
- Test temperature: 20.3 – 22.2°C
- Suspended solids concentration: 4.3 g/L.
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 2 (2 L Duran bottles)
- Method used to create aerobic conditions: vessels were sparged with a supply of CO2-free air.
- Measuring equipment: (IC) concentration was determined using the Suez TOC analyser system
- Details of trap for CO2 and volatile organics if used: barium hydroxide solution
SAMPLING
- Sampling frequency: day 2, 5, 7, 9, 12, 16, 21, 26, and 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 2 replicates
- Toxicity control: yes, 1 replicate - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 69
- Sampling time:
- 28 d
- Details on results:
- The mean total CO2 production in the blank control vessels was 27.45 mg/L on Day 28
Toxicity Control:
The test item was not considered to have an inhibitory effect on the inoculum because the 25% biodegradation level (calculated on total theoretical carbon content of vessel) was achieved in the Toxicity Control (containing the reference substance and the test item) between Day 2 and 5 (Day 2 = 14.7%; Day 5 = 30.5%). - Results with reference substance:
- The mean percentage biodegradation of the reference substance was > 60% by Day 7 and at the end of the test (Day 29 - post acidification) the mean percentage biodegradation of the reference substance was 87.3% (vessel 3: 91.1%; vessel 4: 83.4%).
- Validity criteria fulfilled:
- yes
- Remarks:
- Please refer to table 2 at "Any other information on results incl. tables"
- Interpretation of results:
- readily biodegradable
Reference
Table 1: Mean degradation rates
|
Test item |
Reference substance |
Toxcity control |
Day 2 |
10.3 |
28.57 |
14.72 |
Day 5 |
28.59 |
51.60 |
30.50 |
Day 7 |
43.55 |
65.92 |
42.01 |
Day 9 |
51.26 |
72.12 |
47.87 |
Day 12 |
55.92 |
76.50 |
51.58 |
Day 16 |
58.96 |
80.16 |
54.91 |
Day 21 |
62.42 |
84.01 |
58.42 |
Day 26 |
65.90 |
84.01 |
61.83 |
Day 28 |
67.38 |
85.94 |
63.91 |
Day 29* |
68.84 |
87.27 |
64.78 |
*refers to the day that titrations of trap content from acidified vessels were performed.Actual acidification was performed on Day 28.
Table 2: Validity criteria for OECD 301B.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
Difference of extremes of replicate values of the removal of the test chemical at the plateau, at the end of the test or at the end of the 10-d window, as appropriate, is less than 20%. |
> 20% |
yes |
Percentage degradation of the reference compound reached the pass level by day 14 (≥ 60%). |
76.50 within 12 d |
yes |
The toxicity control should degrade to at least 35% (based on DOC) or at least 25% (based on ThOD or ThCO2) within 14 d. |
51.58% within 14 d |
yes |
The IC content of the test substance suspension in the mineral medium at the beginning of the test must be less than 5% of the TC. |
<5% |
yes |
The total CO2 evolution in the inoculum blank at the end of the test should not normally exceed 40 mg/L medium. |
27.45 mg/L on day 28 |
yes |
Description of key information
Readily biodegradable: 87.3% (CO2 evolution) in 28 days (OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The assessment is based on the data currently available. New studies, based on the category review and the final decisions issued for some of the category substances, which are also relevant for this assessment, are currently being conducted. The hazard assessment with respect to aquatic toxicity will be updated once all ongoing studies have been finalised.
In a screening study investigating the ready biodegradability of Alcohols, C16-18 and C18-unsatd., ethoxylated, sulfates, sodium salts a degradation rate of 69 % after 28 days was determined. The study was conducted according to OECD 301B using activated sludge from a municipal wastewater treatment plant as incoulum. The degradation rate was determined by measuring the CO2 evolution of the activated sludge organisms during the 28 day incubation period.
Based the results, the substance is considered readily biodegradable according to OECD criteria.
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