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EC number: 211-219-8 | CAS number: 634-93-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- This study was designed to access the effect of the substance 2,4,6-trichloroaniline on the luminescent bacteria Photobacterium phosphoreum carried out for 30 minutes.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,4,6-trichloroaniline
- Molecular formula (if other than submission substance): C6-H4-Cl3-N
- Molecular weight (if other than submission substance): 196.464
- Smiles notation (if other than submission substance): c1(c(cc(Cl)cc1Cl)Cl)N
- InChl (if other than submission substance): 1S/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
- Substance type: organic - Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- Photobacterium phosphoreum
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 30 min
- Remarks on exposure duration:
- 5, 15 and 30 minutes
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 4.61 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibition of luminescence
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the inhibition of luminescence of Photobacterium phosphoreum, the EC50 was observed at 4.61 mg/l.
- Executive summary:
This study was designed to access the effect of the substance 2,4,6-trichloroaniline on the luminescent bacteria Photobacterium phosphoreumcarried out for 30 minutes. Before testing chemical was analyzed by HPLC. Based on the inhibition of luminescence of Photobacterium phosphoreum, the EC50 was observed at 4.61 mg/l. Based on the EC50, chemical can be consider as toxic.
Reference
Description of key information
Study was designed to access the effect of the substance 2,4,6-trichloroaniline on the luminescent bacteria Photobacterium phosphoreum carried out for 30 minutes. Before testing chemical was analyzed by HPLC. Based on the inhibition of luminescence of Photobacterium phosphoreum, the EC50 was observed at 4.61 mg/l. Based on the EC50, chemical can be consider as toxic.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 4.61 mg/L
Additional information
Based on the experimental data from various database for the target chemical study have been reviewed to determine the mode of action of2,4,6-trichloroaniline (CAS no. 634-93-5)on the growth and other activity of microorganisms. The studies are as mentioned below:
In the first key study from peer reviewed journal 2007, study was designed to access the effect of the substance 2,4,6-trichloroaniline on the luminescent bacteria Photobacterium phosphoreum carried out for 30 minutes. Before testing chemical was analyzed by HPLC. Based on the inhibition of luminescence of Photobacterium phosphoreum, the EC50 was observed at 4.61 mg/l. Based on the EC50, chemical can be consider as toxic.
First key study was supported by the second study from secondary sources 1987, 30 minutes study was conducted in which toxicity were measured on the basis of inhibition of luminescence of Pseudomonas putida. Based on the inhibition of cell multiplication after 30 minutes exposures, the EC10 of the test material 2, 4, 6-trichloroaniline is observed to be > 21 mg/L in Pseudomonas putida.
Similar study from same sources 30 minutes study was conducted in which toxicity were measured on the basis of inhibition of luminescence of Photobacterium phosphoreum. Toxicity effect of the test material 2, 4, 6-trichloroaniline was studied in Photobacterium phosphoreum. The toxicity effect were observed based on inhibition of luminescence during 30 minutes period. The EC50 is determine to be 4.60 mg/L.
Based on the above data, it was observed that the toxicity value ranges from 4.60 to > 21 mg/l.
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