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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, QSAR model validation study, published in peer reviewed literature, no restrictions, fully adequate for assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
publication
Title:
A simple dermal absorption model: Derivation and application
Author:
ten Berge, W.
Year:
2009
Bibliographic source:
Chemosphere, 75, 1440-1445

Materials and methods

Principles of method if other than guideline:
Dermal absorption was predicted using a model based on QSAR.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Toluene
EC Number:
203-625-9
EC Name:
Toluene
Cas Number:
108-88-3
Molecular formula:
C7H8
IUPAC Name:
toluene

Results and discussion

Percutaneous absorption
Parameter:
percentage
Absorption:
3.6 %
Remarks on result:
other: maximum dermal flux = 0.000581 mg/cm2/min

Applicant's summary and conclusion

Conclusions:
Dermal absorption of toluene was predicted using the model of ten Berge to be approximately 3.6% with a predicted maximum flux of 0.000581mg/cm2/min.
Executive summary:

The dermal absorption of toluene was predicted using a model which considers dermal absorption as a two stage process, permeation of the stratum corneum followed by transfer from the stratum corneum to the epidermis. The QSAR for each process was derived by fitting each model equation to experimentally derived values using an iterative non-linear least squares approach. Dermal flux and percent absorption were predicted using physicochemical values (see section 4) using values determined at approximately 25C.

The model predicted a maximum flux = 0.0000581 mg/cm2/min giving an absorption of approximately 3.6%.