Diiron tris(sulphate)

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

publication

Title:

A Fatal case of acute ferric chloride poisoning.

Author:

Ling W, Chen-Chang Y, Jiin G, Jou-Fang D

Year:

1988

Bibliographic source:

PMID 9467207 Vet Human Toxicol 40(1):31-4.

Materials and methods

Study type:

human medical data

Endpoint addressed:

acute toxicity: oral

Test material

Test material information

Constituent 1

Reference substance name:

Iron trichloride

EC Number:

231-729-4

EC Name:

Iron trichloride

Cas Number:

7705-08-0

Molecular formula:

FeCl3

IUPAC Name:

iron(3+) trichloride

Results and discussion

Results:

A 25 year old woman fatally ingested 200 mL ferric chloride solution (pH 1), equivalent to 230 mg/kg bw of elemental iron. She had hypoxemia and severe metabolic acidosis with respiratory alkalosis initially. Three hours after her ingestion she presented with drowsy consciousness, tachycardia, tachypnea and projected vomiting. Laboratory studies showed leukocytosis, elevated glucose, aspartate aminotransferase, amylase, lactate dehydrogenase and total bilirubin, coagulation defect and haemolysis. Aspiration and vision loss were also reported. Four hours after ingestion cardiopulmonary arrest suddenly occurred after severe vomiting and the woman died. Toxicological studies showed marked elevation of serum iron (2440 µg/dL).