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Diss Factsheets
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EC number: 233-054-0 | CAS number: 10026-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Test conducted prior to guideline adoption
- Deviations:
- yes
- Remarks:
- No test substance or animal environmental condition details.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Silicon tetrachloride
- EC Number:
- 233-054-0
- EC Name:
- Silicon tetrachloride
- Cas Number:
- 10026-04-7
- Molecular formula:
- Cl4Si
- IUPAC Name:
- tetrachlorosilane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % in corn oil
- Amount of vehicle: No data
- Justification for choice of vehicle: No data
- Purity: No data - Doses:
- 158, 200, 251 and 316 mg/kg bw
- No. of animals per sex per dose:
- Five animals per dose (some doses had two male and three female, others had three male and two female)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: At least 8 days (animals died up to day 8, but no other information).
- Frequency of observations and weighing: Observations for clinical signs of toxicity were made - no further details given.
- Necropsy of survivors performed: no
- Other examinations performed: macroscopic examination of animals that died. - Statistics:
- Mortality data was used for calculation of the LD50 and was done according to modification of the method of EJ de Beer.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 238 mg/kg bw
- 95% CL:
- > 205 - < 275
- Mortality:
- There were 0, 1, 4 and 4 deaths in the 158, 200, 251 and 316 mg/kg bw. Survival time was several hours to eight days with most deaths occurring in four to eight days.
- Clinical signs:
- other: Symptoms included prostration and dyspnea in 30 minutes. Severe diarrhea and loss of appetite were noted.
- Gross pathology:
- Severe inflammation of the gastric mucosa was noted. The intestinal tract was gaseous and irritated. Liver and renal congestion was noted.
- Other findings:
- No other findings reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- In the acute oral toxicity study, conducted according to a protocol similar to the now-delete OECD Test Guideline 401 and pre-GLP, an LD50 for silicon tetrachloride was concluded to be 238 mg/kg bw in rats.
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