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EC number: 246-910-3 | CAS number: 25376-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The vapour of the test substance was blown into the experimental enclosure of 0.4 m3. The rats weighed 172-182 g, and 20 were used. The rats were observed daily, weighed weekly, and clinically examined at the end of the exposure. Blood samples from 5 rats were examined, and liver and kidney function tests were conducted on groups of 5 rats. At the end of the exposure the rats were anaesthetized with ether, and bled to death. The dissected animals were macroscopically examined. Various organs of the killed rats were weighed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diaminotoluene
- EC Number:
- 246-910-3
- EC Name:
- Diaminotoluene
- Cas Number:
- 25376-45-8
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3-methylbenzene-1,2-diamine
- Details on test material:
- 2,4/2,6-Toluylendiamine (80/20)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 4 hr/day, 5 consecutive days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.083 mg/l.
Basis:
analytical conc.
- No. of animals per sex per dose:
- 20 for dose group; animal number of control group not given
- Control animals:
- yes, sham-exposed
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 0.083 mg/L air (analytical)
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
At a concentration of 0.083 mg/l (83 mg/m3) the exposed rats were similar to the
controls in appearance and condition. The exposed rats had reduced body weight
gain. The blood tests showed that the exposed rats had relative lymphopenia. The
liver and kidney function tests were normal. Dissection of the killed rats did
not find any compound related changes. The liver, kidney, and thyroid/body weight
ratios were increased.
In another similar study using a concentration of 0.0095 mg
2,4/2,6-TDA/l (9.5 mg/m3) the treated rats did not significantly differ
from the control animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.