Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-122-9 | CAS number: 78-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well reported non-guideline study.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: HRIPT by modified Shelanski procedure
Test material
- Reference substance name:
- Tris(2-butoxyethyl) phosphate
- EC Number:
- 201-122-9
- EC Name:
- Tris(2-butoxyethyl) phosphate
- Cas Number:
- 78-51-3
- Molecular formula:
- C18H39O7P
- IUPAC Name:
- tris(2-butoxyethyl) phosphate
Constituent 1
Method
- Type of population:
- general
- Route of administration:
- dermal
- Details on study design:
- 1st application: Induction undiluted occlusive epicutaneous
2nd application: Challenge undiluted occlusive epicutaneous
Results and discussion
- Results of examinations:
- Symptoms:
- Frequency, level, duration of symptoms observed:
Signs of irritation during induction: minimal erythema: 5/209 on single occasion; 4/209 on 2 occasions
No. of persons with/out reactions compared to study population:
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 209
- Number of subjects with equivocal reactions: 0
- Number of subjects with irritating reactions: 5
Any other information on results incl. tables
From an original panel of 212 volunteers 209 completed the study. During the induction period minimal irritation was observed on one/two occasions in 9/209 subjects. In 5 of these individuals irritation was observed only once during the 12 applications. In the remaining 4 volunteers irritation was observed twice. All individuals concerned showed minimal erythema only. There was no dermal reaction to challenge.
Applicant's summary and conclusion
- Conclusions:
- TBEP was not sensitizing in this test.
- Executive summary:
TBEP was tested in a human repeated insult patch test (HRIPT) using the modified Shelanski procedure. Of the 209 volunteers subjected to a three week induction period 47 were male and 162 female. A site on the back of each individual was identified as the intact contact site. Approximately 0.2ml of TBEP, as supplied, was placed on a webril pad of the bandage and the patch then applied to the designated site. A series of 12 applications of 24-h duration was conducted at the rate of 4 applications per week during the 3-week induction period. During the 4th week a series of four challenge applications on virgin sites was completed. All reactions were scored on a scale of 0 to 4.
During the induction period minimal irritation was observed on one/two occasions in 9/209 subjects. In 5 of these individuals irritation was observed only once during the 12 applications. In the remaining 4 volunteers irritation was observed twice. All individuals concerned showed minimal erythema only. There was no dermal reaction to challenge. It was concluded that TBEP did not induce sensitization in this test procedure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)