Registration Dossier
Registration Dossier
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EC number: 211-745-8 | CAS number: 693-21-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment from available information
- Adequacy of study:
- key study
- Study period:
- January 2012 - March 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific method and is described in sufficient detail.
Data source
Reference
- Reference Type:
- other: Final report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Oxydiethylene dinitrate
- EC Number:
- 211-745-8
- EC Name:
- Oxydiethylene dinitrate
- Cas Number:
- 693-21-0
- Molecular formula:
- C4H8N2O7
- IUPAC Name:
- 2-[2-(nitrooxy)ethoxy]ethyl nitrate
Constituent 1
Results and discussion
Any other information on results incl. tables
Experimental data - No data available.
Literature data (internet search) - Literature data were found in free accessible reports on internet.
- Acute toxicity – oral, dermal, eye irritation, skin sensitisation
- Mutagenicity and carcinogenity
Data from databases RTECS, MEDLINE and HSDB - These data are summarized in following sections:
- Human exposure excerpt
- Non-Human Toxicity excerpt – Toxicity studies:
- Acute toxicity – oral
- Acute toxicity – dermal
- Acute toxicity – inhalation
- Acute toxicity – eye irritation
- Acute toxicity – skin irritation
- Acute toxicity – skin sensitization
- Chronic toxicity
- Genotoxicity
- Chronic exposure and carcinogenity
- Reproduction
- Pharmacokinetics in mammals
Applicant's summary and conclusion
- Conclusions:
- Probable Routes of Human Exposure
Occupational exposure to Diethylene glycol dinitrate may occur through dermal contact with this compound at workplaces where diethyleneglycol dinitrate is produced or used. Limited exposure to general population to diethyleneglycol dinitrate may occur via inhalation. In sporadic cases the acute oral poisoning is encountered.
Toxicokinetics Evaluation Summary
The substance is not absorbed through the skin. After oral or inhalation exposure it is fairly quickly absorbed and systemically distributed through the body (hours). Through the blood circulation it reaches and influences the heart, CNS, liver and kidneys, etc.
In the body the nitrate form is converted to nitrite form which causes the most of symptoms observed after exposition. It seems that the elimination through the kidneys to the urine takes several days after both the lower and higher doses.
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