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Diss Factsheets
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EC number: 210-539-5 | CAS number: 617-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: WoE: The available LD50s range from ± 1000 – 3000 mg/kg bw.
Inhalation: No valid studies are available. The available study gets a K4 since no original references are available only secondary references. No LD50 is available, no LD50 available, data is not sufficient for C&L purposes.
This substance is a transported isolated intermediate and therefore no additional testing is warranted.
Dermal: No valid studies are available. The available study gets a K4 since no original references are available only secondary references. The available LD50 is 4300 mg/kg bw. Since only one secondary reference is available the data is not sufficient for C&L purposes.
This substance is a transported isolated intermediate and therefore no additional testing is warranted.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary references: WoE
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Remarks on result:
- other: see Any Other Information
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Since no original references are available only secondary references all available data is K4. The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
- Executive summary:
Since no original references are available only secondary references all available data is K4. The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
Reference
Acute oral
|
WoE Since no original references are available only secondary references all available data is K4. The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
Classification and Labeling Acute oral Category 4. |
LD50 rat: 1300 mg/kg (1000-1700 mg/kg)
The acute oral LD50 for 2-phenyl-2-propanol in rats was reported to be 1.3 g/kg (1.0–1.7 g/kg). Rats (10/dose) were dosed by orally at doses of 0.6, 0.85, 1.22, 1.73, 2.47, and 5.0 g/kg. Mortalities were 0, 3, 4, 6, 10, and 10 with increasing does; all animals died within 2 days of dosing. Clinical observations included lethargy, ataxia, loss of righting reflex, and coma. Necropsy observations included oral and nasal excretions, redness, yellowing and bloating in the intestines, red areas in stomach, dark lungs, and dark and/or mottled kidneys, |
Moreno. O. M. (1977). Report to RIFM. 7 October. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982
RIFM (Research Institute for Fragrance Materials, Inc.), 1977a. Acute Toxicity Study in Rats, Rabbits and Guinea Pigs. RIFM Report No. 1695, April 08. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3.
|
LD 50 rat: 1.07 ml/kg (± 1 g/m3, ± 1000 mg/kg) |
Union carbide corp. unpublished data. Cited in:Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687 |
The oral LD50 in the rat ranged from 1400 to 3000 mg/kg. The oralLDin the rat of a mixture of 75% of the substance and 25% acetophenone was found to be 2000 mg/kg. |
HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743 |
LD50 rat: 2250 mg/kg With clinical signs of toxicity similar to those of narcotics |
Bukhalovskii, A. A. & Shugaev, B. B. (1976). Toksichnost i gigienicheskoe normirovanie izoforona, digidroizoforona i dimetilfenilkarbinola.Promyshlennost Sillleticheskogo Kauchuka1976 (2), 4. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982 |
LD50 mice: 1950 mg/kg With clinical signs of toxicity similar to those of narcotics |
Bukhalovskii, A. A. & Shugaev, B. B. (1976). Toksichnost i gigienicheskoe normirovanie izoforona, digidroizoforona i dimetilfenilkarbinola.Promyshlennost Sillleticheskogo Kauchuka1976 (2), 4. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of acute toxicity – oral endpoint
Since no original references are available only secondary references all available data is K4.
The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
Justification for classification or non-classification
Acute oral: Since no original references are available only secondary references all available data is K4.
The available LD50s range from ± 1000 – 3000 mg/kg bw. Since most of the values are < 2000 mg/kg the substance is classified for acute oral toxicity: Acute oral Category 4.
Acute inhalation: No LD50 available, data is not sufficient for C&L purposes.
Acute dermal: Since only one secondary reference is available the data is not sufficient for C&L purposes.
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