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EC number: 812-958-4 | CAS number: 1078712-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 2, 2016 to February 21, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 1078712-76-1
- Molecular formula:
- C23-27H49-59N (Substance is a UVCB)
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Test water samples were collected from the batches of test solution prepared for each treatment and
control group at the beginning of the test and from each test chamber at 48 hours (± 1 hour) to measure
concentrations of the test substance. Ten milliliter aliquots of all the samples were collected from mid-depth,
placed in glass vials containing 10.0 mL of 0.2% formic acid in methanol, and processed immediately for
analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test substance was administered to the test organisms in water. This route of administration was
selected because it represents the most likely route of exposure to aquatic organisms. Since the test substance
is poorly soluble in water, individual test solutions were prepared in the form of water accommodated
fractions (WAF) for each loading rate of 1.9, 4.3, 9.4, 21, 45 and 100 mg/L in a 4.5 L Pyrex™ aspirator with
tubulation and spigot approximately 2-3 cm from the bottom. 4-L of dilution water was measured using a
calibrated plastic bucket and emptied into labeled WAF bottles. For each loading rate, an appropriate amount
of the test material was weighed onto plastic weigh boats and then was rinsed with a portion of the dilution
water into the appropriate WAF bottles. Each test solution was stirred on a stir plate with a Teflon-lined stir
bar, with a vortex depth of approximately 30% of the test solution height for 23 hours. The negative control
was dilution water only.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 140 mg/L as CaCO3
- Test temperature:
- 20 +/- 1 C
- pH:
- 8.1-8.5
- Dissolved oxygen:
- > 8.2 mg/L
- Conductivity:
- 336 uS/cm
- Nominal and measured concentrations:
- Nominal WAF Loading Rates
Negative Control
1.9 mg/L
4.3 mg/L
9.4 mg/L
21 mg/L
45 mg/L
100 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 1.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: lethargy
Any other information on results incl. tables
Results of analyses to measure concentrations of Amines, (2-ethylhexyl)(hydrogenated tallow
alkyl)methyl in the test solutions samples collected during the test are presented in Table 1. Measured
concentrations from day 0 and 48 hour sample analysis ranged from approximately < LOQ to 1.07% of
nominal. When measured concentrations of the samples collected during the test were averaged, the mean
measured test concentrations for this study were 0.01, 0.02, 0.03, 0.02, 0.16 and 0.07 mg/L, representing 0.53,
0.47, 0.32, 0.10, 0.36 and 0.066% of nominal loading rates, respectively. Since the test substance is poorly
soluble in water, the individual test solutions prepared as water accommodated fractions (WAF) for each
loading rate were all above the solubility limit of the test substance. The resulting measured concentrations
were variable, but essentially equivocal despite differences in loading rate, and incorporating a lengthy
mixing procedure. Therefore, the results of the study were interpreted based on the nominal loading rates.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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