Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-232-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 June 1993 to 5 January 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- no analytical determination
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- no analytical determination
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- All test medium samples for the analytical determinations were taken after mixing of the test solutions from the approximate center of the test vessels and kept at -18°C to -25 °C until analyses.
- Vehicle:
- no
- Details on test solutions:
- 0.5 g test substance were mixed with 200 ml test medium and fill up to 500 ml with test medium. The stock solution was homogenized for ten minutes in the supersonics bath.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test organism was the species Daphnia magna. The daphnids were bred in the laboratories of the Textile Dyes Division, Product Ecology TF under standardized conditions. For the test, animals with age of less than 24 hours were used. The quality of the daphnids will be checked at least every 3 months by determining the EC50 values (24 h) for potassium dichromate (range: 0.8 -1.5 mg/l).
For each concentration, 20 Daphnia magna were used. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No post exposure observation period specified.
- Hardness:
- 136 mg/l CaCO3
- Test temperature:
- 21.2 - 21.9°C
- pH:
- 7.9 - 8.1
- Dissolved oxygen:
- 97%
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- Based on a pretest, the test concentrations were chosen as 58 mg/l, 100 mg/l and 180 mg/l nominal
- Details on test conditions:
- 48 hours at 21°C, 16 hours light / 8 hours darkThe daphnids were exposed to the test article in 250 ml beakers containing 100 - 200 ml test medium with 10 animals per beaker. All tests are running in duplicate. During exposure the animals were kept at 21 ± 1°C with 16 hours illumination.Test evaluations were done according to the guidelines by visual assessment of mobility of the daphnids after 24 and 48 hours.The EC50 was evaluated directly from the test concentrations.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The test substance is not soluble in water and organic solvents. Therefore, the concentrations of the test substance could not be determined.
In the control and in all test concentrations no immobilization of the daphnids was observed after 48 hours. The EC 0 value is > 180 mg/l. The EC 50 and EC 100 values are clearly higher than 180 mg/l nominal. - Results with reference substance (positive control):
- Reference substance not tested in this study.
- Reported statistics and error estimates:
- Not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 >180 mg/l nominal
The test material was practically non toxic to Daphnia magna. - Executive summary:
The acute toxicity of the test material to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 84/449, L 251, Part C 2.
The test was performed in compliance with the Good Laboratory Practice Regulations.
The test substance is not soluble in water and organic solvents. Therefore, the concentration of the test substance could not be determined.
The nominal concentrations tested were 58 / 100 and 180 mg test article/l, and a control without any additions.
In the control and in all test concentrations no immobilization of the daphnids was observed after 48 hours. The EC 0 value is > 180 mg/l. The EC 50 and EC 100 values are clearly higher than 180 mg/l nominal.
Therefore, the EC 50 could not be calculated.
Results :
EC0 >180mg/l nominal
EC50 > 180mg/l nominal
EC100 >180mg/l nominal
Conclusion: The test material is practically non toxic to Daphnia magna.
Reference
Conc. of Test substance (mg/l nominal) |
No. of animals |
No. of responses |
% immobility |
||
24 h |
48 h |
24 h |
48 h |
||
Blank |
10 10 |
0 0 |
0 0 |
0 |
0 |
58 |
10 10 |
0 0 |
0 0 |
0 |
0 |
100 |
10 10 |
0 0 |
0 0 |
0 |
0 |
180 |
10 10 |
0 0 |
0 0 |
0 |
0 |
The EC values are evaluated as follows: (mg/l)
Time |
EC 0 |
EC 50 |
EC 100 |
After 24 h After 48 h |
≥180 ≥180 |
>180 >180 |
>180 >180 |
FAT-45’019/E is considered to be practically non-toxic to daphnids
Description of key information
Key value determined in a GLP accredited laboratory study performed in accordance with OECD Guideline 202 and EU Method C 2.
According to this test, the substance is practically non-toxic to Daphnia magna
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 180 mg/L
Additional information
The acute toxicity of the test material to Daphnia magna was determined in a GLP study performed in accordance with OECD Guideline 202 and EU Method C.2. The nominal concentrations tested were 58 mg/L, 100 mg/L and 180 mg/L, and a control without any additions. The control and all test concentrations did not cause any immobilization of the daphnids after 48 hours. The EC0 value is > 180 mg/L. The EC50 and EC100 values are clearly higher than 180 mg/L nominal. The test substance is not soluble in water and organic solvents therefore measured concentrations could not be determined. It is concluded that the substance is practically non-toxic to Daphnia magna.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.