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Diss Factsheets
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EC number: 939-200-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitisation potential of the Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyratewas investigated in a skin sensitisation study conducted according to OECD Test Guideline 429 using the local lymph node assay (Valiczko, 2013). In the study, a Preliminary Irritation /toxicity test was carried out in which CBA/J Rj mice were treated with the test substance, sodium isobutyrate solution, at 50% or 100% w/v in 1 % Pluronic. On the basis of this test, 100% w/v was selected as the top dose for the main assay.
In the main assay, twenty female CBA/J Rj mice were allocated into five groups of four: three groups were treated with the test substance (formulated in 1% Pluronic) at 25, 50 and 100% w/v; the negative control group received the vehicle (1% Pluronic) and the positive control group received 25% w/v α-Hexylcinnamaldehyde (HCA) dissolved in 1% Pluronic. The test item solutions were applied on the dorsal surface of the ears of mice at 25 μL/ear for three consecutive days (Days 1, 2 and 3), with no treatment being administered on Days 4,5 and 6. On day 6, the cell proliferation in the local lymph nodes and the results were used to calculate stimulation indices (SI).
No mortalities or systemic clinical signs were observed during the study. The observed stimulation index values were 1.5, 1.9 and 0.9 at concentrations of 100, 50 and 25% (w/v) respectively. Under the conditions of this study, treatment with sodium isobutyrate solution at concentrations up to 100% did not cause skin sensitisation. On this basis, the Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyrateis not a skin sensitiser.
There is no indication from the experience of use that this substance can cause skin sensitisation in exposed workers.
Migrated from Short description of key information:
The Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyrate was not found to cause skin sensitisation in a study conducted using the local lymph node assay. There is no evidence from the experience of use that the substance has the potential to cause skin or respiratory sensitisation in exposed workers.
Justification for selection of skin sensitisation endpoint:
Sole study providing data from a guideline compliant study. Under the conditions of the study, the test substance was not found to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There is no indication from the experience of use that the Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyratecan cause respiratory sensitisation in exposed workers.
Migrated from Short description of key information:
There is no indication from the experience of use that the Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyrate can cause respiratory sensitisation in exposed workers.
Justification for selection of respiratory sensitisation endpoint:
There is no indication from reports in exposed workers that the substance can cause respiratory sensitisation (occupational asthma).
Justification for classification or non-classification
The Reaction mass of lithium 3-hydroxy-2,2,4-trimethylpentanoate and lithium isobutyrate and sodium 3-hydroxy-2,2,4-trimethylpentanoate and sodium isobutyratedid not cause skin sensitisation in a study conducted using the local lymph node assay. The substance does not meet the criteria for classification for skin or respiratory sensitisation according to Directive 67/548/EEC or Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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