Registration Dossier
Registration Dossier
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EC number: 700-161-3 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (growth rate) > 120 mg/L based on nominal concentrations of TNS (22.44 mg/L based on 18.7% a.i.) and NOEC (growth rate) = 120 mg/L based on nominal concentrations of TNS (22.44 mg/L based on nominal 18.7% a.i.) are corroborated by the read across from Zonyl.
Key value for chemical safety assessment
Additional information
Zonyl and TNS are considered sufficiently similar to facilitate read-across of this data endpoint. A non GLP study with TNS gave rise to the following result for algae: EC50 (biomass) > 120 mg/L based on nominal concentrations of TNS ( > 22.44 mg/L based on 18.7% a.i.). For Zonyl, the EC50 (biomass) was > 100 mg/L based on nominal Zonyl concentrations ( > 35 mg/L based on nominal 35% a.i.). Because mean measured test concentrations were within 80% of nominal test concentrations, endpoints for the Zonyl study were based on nominal Zonyl test concentrations. Data from the guideline GLP study with Zonyl are consistent with the results of the non-GLP study with TNS. As part of a weight of evidence approach, these two studies adequately address the information requirements for algae and aquatic plants.
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