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EC number: 619-547-7 | CAS number: 211515-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- February 01,2007 to October 07,2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- - The OECD Principles of Good Laboratory Practice (as revised in 1997) ENV/MC/CHEM(98)17 - Chemikaliengesetz (, Chemicals Act 7 der Bundesrepublik Deutschland (ChemG), Anhang 1 (,Annex I 7, 2002 - Directive 2004/1 O/EC of 11 February 2004 (Official Journal No. L 50/44)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2 1 15 15-46-7
- IUPAC Name:
- 2 1 15 15-46-7
- Details on test material:
- Name: CAT - Acid chloride
CAS No.: 2 1 15 15-46-7
Certificate of Analysis Date: March 30,2006
Type: Active ingredient of a pharmaceutical
Aggregate State at Room Temperature: Liquid (according to IBACON personnel)
Colour: Brown (according to BACON personnel)
Stability : Technical product:
Expiry Date: July 03,2007
Storage: In original container, in the refrigerator (2-8 degree C), in the dark.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24 and 48 exposure durations
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 3.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 4.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 7.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 21.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Results:
After 48 hours of exposure no immobilization of the test animals was observed in the control and the test item concentration of 2.2 mg/l mean measured. At the concentration of 4.5 mg/l mean measured six animals were immobile and all 20 animals were immobile at the concentration of 53 mg/l mean measured (filtrate).
Analytical Method:
The test item was analysed using a TOC method.
Analytical Results:
At the start of the test 44% of the nominal test concentration
was found (mean value of the two highest test concentrations).
This calculation based on nominal test concentrations not
considering the fact that the test media were filtrated to remove
the non-dissolved part of the test item. Therefore, these reduced
findings are not surprising. In the aged test media 56% of the
nominal value was determined (mean value of the two highest
test concentrations). Thus, during the test period the daphnia
were exposed to a mean of 50% of nominal (mean value of the
two highest test concentrations). Therefore, the results of the
two highest concentrations (filtrate and one dilution) are
expressed in terms of mean measured concentrations of the test
item. For the three lowest concentrations under the limit of
quantification the concentration was calculated by multiplying
the nominal value with the overall mean recovery from the two
highest concentrations (50%).
TOC analysis cannot differ between test item and degradation
products (both of them contribute to the signal, which is
evaluated). However, for the calculation of the recovery rate
this has not to be considered.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Conclusion:
The toxic effect of the test item CAT - Acid chloride to
Daphnia magna was assessed in a static dose-response test. The
48-hour EC50 value was 11.0 mg test item/l. - Executive summary:
Title:
Acute Toxicity of CAT - Acid chloride to Daphnia magna in a Static 48-
hour Immobilization Test
Guidelines:
- Commission Directive 92/69/EEC, Annex Part C, C.2: "Acute Toxicity
for Daphnia",Official Journal of the European Communities No.
L 383 A, dated December 29, 1992
- OECD Guideline for Testing of Chemicals 202:"Daphnia sp., Acute
Immobilisation Test" adopted April 13,2004.
Material and methods:
Test Item:
CAT - Acid chloride
Test Species:
Female Daphnia magna,clone 5; 6.5 to 22.5 hours old, source: ECT
Oekotoxikologie GmbH, Böttgerstr. 2 - 14, 65439 Flörsheim am Main,
Germany.
Test Design:
This study encompassed 6 treatment groups (a filtrate of the test item and 4
dilutions as well as a control) each containing 20 individuals. The
immobility of the Daphnia was determined in a static 48-hour test by visual
controls after 24 and 48 hours.
Since the test item is instable and insoluble in test water, it was tested
according to OECD No. 23 (Testing of Difficult Substances). Therefore, the
stock solution was stirred for 24 hours, in order to make allowance for the
water insolubility of the test item. The non-dissolved part of the test item
was afterwards removed by filtration. Due to the instability of the test item,
mainly the degradation products were tested.
The purpose of the analytical part of this study was to measure the dissolved
part of the test item and/or its degradation products using measurement of
Total Organic Carbon (TOC) as sum parameter.
Endpoints:
Number of immobile organisms after 48 hours.
Test Rates:
Control, filtrate of nominal 100 mg test item, the dilutions 1:2.2, 1:4.8,
1:11, 1:23 of this filtrate (corresponding to mean measured values of 53,
21.4, 10.4, 4.5 and 2.2 mg/l). The test media were prepared just before
introduction of daphnia (= start of the test).
Test Conditions:
Water temperature: 19 degree C - 2O degree C; photoperiod: 16 h light - 8 h dark; light
intensity: 58 - 146 lux; dissolved oxygen concentration: 6.9 to 8.6 mg/l; pH
value: 6.7 to 7.6; and thus were within the ranges requested by guideline
OECD 202
Results:
After 48 hours of exposure no immobilization of the test animals was observed in the control and the test
item concentration of 2.2 mg/l mean measured. At the concentration of 4.5 mg/l mean measured six
animals were immobile and all 20 animals were immobile at the concentration of 53 mg/l mean measured (filtrate).
Analytical Method:
The test item was analysed using a TOC method.
Analytical Results:
At the start of the test 44% of the nominal test concentration
was found (mean value of the two highest test concentrations).
This calculation based on nominal test concentrations not
considering the fact that the test media were filtrated to remove
the non-dissolved part of the test item. Therefore, these reduced
findings are not surprising. In the aged test media 56% of the
nominal value was determined (mean value of the two highest
test concentrations). Thus, during the test period the daphnia
were exposed to a mean of 50% of nominal (mean value of the
two highest test concentrations). Therefore, the results of the
two highest concentrations (filtrate and one dilution) are
expressed in terms of mean measured concentrations of the test
item. For the three lowest concentrations under the limit of
quantification the concentration was calculated by multiplying
the nominal value with the overall mean recovery from the two
highest concentrations (50%).
TOC analysis cannot differ between test item and degradation
products (both of them contribute to the signal, which is
evaluated). However, for the calculation of the recovery rate
this has not to be considered.
Conclusion:
The toxic effect of the test item CAT - Acid chloride to
Daphnia magna was assessed in a static dose-response test. The
48-hour EC50 value was 11.0 mg test item/l.
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