Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-372-6 | CAS number: 98730-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Half-life of 40.1 days at pH 7 and 25 °C (Kuet, 2002)
Normalised half-life of 113.5 days at 12 °C
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 40.1 d
- at the temperature of:
- 25 °C
Additional information
A number of studies are available concerning the hydrolysis of CGA154281 (benoxacor).
The first study (Warren, 1986) investigated the degradation of benoxacor through hydrolysis. Only minimal hydrolysis was observed at pH 3. The half-lives at pH 7 and pH 11 were estimated to be 46 and 19 days, respectively. This non-guideline study was conducted to GLP.
In the second study (Spare, 1987) benoxacor was found to undergo significant hydrolysis at pH 7.0 and 9.0 with half-lives of 56 and 13 days, respectively. No significant hydrolysis was observed at pH 5. This GLP-compliant study was conducted to US EPA guideline for hydrolysis and is considered to be reliable without restrictions.
The third study (Kuet, 2002) was a GLP-compliant study conducted to OECD111. This study is considered to be reliable without restrictions. Hydrolysis was negligible at 25°C at pH 4.0 and pH 5.0. The reported half-lives for benoxacor at 25°C were 40.1 and 24.2 days at pH 7.0 and pH 9.0, respectively. Hydrolysis was faster at higher temperatures.Only one major degradation product was formed, CGA 201068, which was identified at levels up to 40.6 and 56.4% at pH7 and pH 9, respectively at 25°C.
Based on the above information, it is concluded that benoxacor is hydrolytically stable under acidic conditions at environmentally relevant temperatures, but prone to hydrolysis under neutral or basic conditions.Under neutral conditions the degradation half life is relatively slow (between 46 and 56 days), but increases with increasing pH (pH9 the DT50 is 13 days). The key value selected for the chemical safety assessment is a half life of 40.1 days at pH 7 and 25 °C, taken from the study by Kuet (2002). This study is considered to be the most reliable as it is the most recent and was performed according to the OECD guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.