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EC number: 275-965-6 | CAS number: 71735-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 28, 1982 to June 8, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP (performed in 1982), no positive control but well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- A single oral administration (by gavage) of the test material at doses of 0, 500 and 2500 mg/kg was administered to male and female rats.
Laboratory investigations were carried out in all rats of each sex and each group at 4 and 24 hours after the administration to determine cholinesterase inhibitory activity of the test material. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- EC Number:
- 275-965-6
- EC Name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- Cas Number:
- 71735-74-5
- Molecular formula:
- C11H23O4PS2
- IUPAC Name:
- ethyl 3-{[bis(propan-2-yloxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}propanoate
- Details on test material:
- - Name of test material (as cited in study report): TK 11950
- Substance type: Organic
- Physical state: Liquid
- Analytical purity: not determined
- Lot/batch No.: 013 IV
- Expiration date of the lot/batch: December 1982
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Production Stein, CIBA-GEIGY AG
- Age at study initiation: approximately 7-8 weeks
- Weight at study initiation: males: 246 +/- 10 g, females: 207 +/- 8 g
- Fasting period before study:
- Housing: by number of cage, in Macrolon cages type 2 with standardised granulated soft wood bedding (Société Parisienne des sciures Pantin)
- Diet (e.g. ad libitum): Pelleted, certified standard diet Nafag No. 890 Tox, ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: 11 days (from May 28, 1982 to June 7, 1982)
Neither insecticides not chemicals were applied in the animal room with the exception of disinfectant: Fungitex SB (Prod. No. 30071, CIBA-GEIGY AG)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2°C
- Humidity (%): 55+/-10%
- Air changes (per hr): 15-17 air changes/hour
- Photoperiod (hrs dark / hrs light): 12h dark / 12h light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
The solutions were freshly prepared immediately prior to the dosing of the animals and administered within 2 hours.
Vehicle: CMC
VEHICLE
- Concentration in vehicle: 0, 500 and 2500 mg test material/kg
- Amount of vehicle (if gavage): 10 mL/kg - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Laboratory investigations carried out at 4 and 24 hours after the administration
- Frequency of treatment:
- Single dose
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day (nominal)
- Dose / conc.:
- 2 500 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- PRETEST:
for control: 4 (2 males and 2 females)
for test: 4 (2 males and 2 females)
MAIN TEST:
for control: 8 (4 males and 4 females)
for test: 8 (4 males and 4 females) - Control animals:
- yes, concurrent vehicle
Examinations
- Observations and clinical examinations performed and frequency:
- The activity of acetylcholinesterase (in plams and red blood cells) was checked by colorimetry (modified acetylthiocholine DTNB method. Voss G. et al. Toxicol. Appl. Pharmacol. 16, 764 (1970))
The blood chemistry was also checked
HYLMD I (Normal) Travenol
HYLAND I I (Abnormal) Travenol
MCNI-TRCL I (Normal) Merz + Dade
MCNI-TOCL I I (Abnormal) Merz + Dade
ROCHE "N" NORMAL Roche Diagnostica
Results and discussion
Results of examinations
- Details on results:
- A single oral administration of the test article to male and female rats at a dose of 500 mg/kg had no inhibitory effect on plasma and RBC cholinesterase activity.
At 2500 mg/kg a slight inhibition of the plasmachollinesterase activity was recorded.
One of the males in the contrl group died during the blood withdrawal procedure.
Applicant's summary and conclusion
- Conclusions:
- A single oral administration of test material to male and female rats at a dose of 500 mg/kg had no inhibitory effect on plasma and RBC cholinesterase activity. A single oral administration of test material to male and female rats at a dose of 2500 mg/kg induced a slight inhibition of the plasma cholinesterase activity.
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