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EC number: 275-269-2 | CAS number: 71215-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of ACDMA in rat was found to be > 5000 mg/kg bw in test performed according to OECD TG 401 and GLP.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987; October 16 to November 10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1981)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna (UK ) Limited, Wyton, Huntingdon, Cambridgeshire
- Age at study initiation: 5-8 weeks old
- Weight at study initiation: 171-175g for males; 150-161g for females
- Fasting period before study: overnight fast immediately before dosing and for approximately two hours after dosing
- Housing: groups of up to 5 by sex in solid-floor poly-propylene cages with sawdust bedding
- Diet (e.g. ad libitum): free access to mains drinking water awas allowed throughout the study.
- Water (e.g. ad libitum): free access to food (Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, t,litham, Essex, U.K.) was allowed throughout the study.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): 45-64
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: For the purpose of this study the test material was ground to a fine powder using a mortar and pestle and freshly prepared as required at the appropriate
concentrations i n 1% aqueous carboxymethyl-celIulose.
- Amount of vehicle (if gavage): 10 mL/kg
All rats were dosed once only by gavage using a metal cannula attached to a graduated syringe. The volume administered to each animal was calculated according to its fasted bodyweight at the time of dosing. - Doses:
- Range-finding study: 2000 and 5000 mg/kg bw
Main study: 5000 mg/kg bw - No. of animals per sex per dose:
- Range-finding study: 1
Main study: 5 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 days (range-finding study); 14 days (main study)
- Frequency of observations: 1 and 4h after dosing; every days between 1 and 14 days after dosing
- Frequency of weighing: Day 0, 7 & 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Preliminary study:
- No death in range-finding study: 0/2 at 2000 mg/kg and 0/2 at 5000 mg/kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: greater than the maximum tested concentration
- Mortality:
- No death: 0/10 at 5000 mg/kg
- Clinical signs:
- other: No clinically observable signs of toxicity were noted during the study.
- Gross pathology:
- Necropsy at the end of the study revealed no macroscopic abnormalities.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of ACDMA in rat was found to be > 5000 mg/kg bw in test performed according to OECD TG 401 and GLP.
- Executive summary:
The LD50 of ACDMA in rat was found to be > 5000 mg/kg bw in test performed according to OECD TG 401 and GLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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