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Diss Factsheets
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EC number: 270-109-8 | CAS number: 68411-20-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- Principles of method if other than guideline:
- 1. 1% modifier (acetonitrile) was added to water.
2. The solubility was tested at pH4 - GLP compliance:
- yes (incl. QA statement)
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- flask method
- Water solubility:
- 5.2 mg/L
- Temp.:
- 20 °C
- pH:
- 4
- Remarks on result:
- other: 1 % organic solvent additive
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
Determination of the water solublity is technically not feasible as the substance reacts quickly in waer forming aniline. In a test similar to OECD Guideline No 105 a water solubility of 5.2 mg/L of the substance in buffer solution pH 4 and addition of 1% acetonitrile was observed. - Executive summary:
The test item is hydrolytically unstable in water but stable in acetonitrile. Therefore a solubility test according to OECD Guideline 105 was carried out based on a stock solution in acetonitrile and different concentration tests of the test item in buffer solution pH 4, containing 1 % acetonitrile were perfomed. A solubility of 5.2 mg/L of the test was observed.
Reference
Concentrations of the test item in buffer solution pH 4 with 1 % organic solvent additive:
Test at 20 °C | Concentration test 1 | Concentration test 2 | Concentration test 3 | Concentration test 4 |
Volume of test solution | 100 µl test solution 1 | 100 µl test solution 2 | 100 µl test solution 3 | 100 µl test solution 4 |
Volume of buffer solution pH 4 | 10 ml | 10 ml | 10 ml | 10 ml |
Concentration of the test item | 104.9 mg/l | 10.49 mg/l | 5.245 mg/l | 2.6225 mg/l |
Appearance | Solution with residue of the test item | Solution with residue of the test item | Solution(limit case) | Solution |
Description of key information
Determination of the water solublity is technically not feasible as the substance reacts quickly in water forming aniline. In a test similar to OECD Guideline No 105 a water solubility of 5.2 mg/L of the substance in buffer solution pH 4 and addition of 1% acetonitrile was observed.
Key value for chemical safety assessment
- Water solubility:
- 5.2 mg/L
- at the temperature of:
- 20 °C
Additional information
The test item is hydrolytically unstable in water but stable in acetonitrile. Therefore a solubility test was carried out based on a stock solution in acetonitrile and different concentration tests of the test item in buffer solution pH 4, containing 1 % acetonitrile were perfomed. It should be noted that the solubility in pure water is expected to be significantly lower, probably < 1mg/L.
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