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Diss Factsheets
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EC number: 259-563-8 | CAS number: 55281-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity in rats
LD50 = 3980 mg/kg, corresponding to 1592 mg/kg a.i..
LD50 = 4970 mg/kg, corresponding to 1759 mg/kg a.i..
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 592 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data on acute oral toxicity of the target substance was available, thus a read across approach was followed using available data on Similar Substance 01. Further details on the read across approach are available in section 13.
Two studies from 1974 and 1986 on acute oral toxicity of Similar Substance 01 were available.
Due to a well-detailed description of test methods and results, the study from 1974 was selected as key study. In both studies, LD50 values were recalculcated based on the active ingredient content, due to the low purity of tested samples, ranging from 35 to 40 % of active ingredient. Remaining components were mainly natural dispersing agents, e.g. sodium lignosulphonate, for which no indication of toxic potential was known.
In the study from 1974, test sample composition is: 40 % dye and remaining as coupage. A preliminary and a main study were conducted, following up and down method as described in J. Amer. Stat. Assoc. 48 (1953), starting from a dose of 5000 mg/kg. Observations for deaths and clinical symptoms were done for 14 days after administration.
In the main study, no symptoms were seen. Deaths occurred between 5 and 48 h after dosing.
Taking into account the 40 % purity of test material, a LD50 value of 1592 mg/kg bw, as active ingredient, was obtained.
In the study from 1986, no details on procedure and results were available. Based on the 35.4 % content of active ingredient, a LD50 of 1759 mg/kg was obtained.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as LD50 (oral, dermal) or LC50 (inhalation) values as well as acute toxicity estimates (ATE).
In available studies in rats, oral LD50 values of 1592 and 1759 mg a.i./kg bw was found.
Based on the available information, the substance was classified for acute oral toxicity in category 4 (LD50 between 300 and 2000 mg/kg bw) in the CLP Regulation (EC 1272/2008).
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